ArticlePulmonary circulation
Pulmonary tumor thrombotic microangiopathy: a systematic review.
Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 113 citations in OpenAlex.
- Safety and Efficacy of Ponatinib for Pulmonary Tumor Thrombotic Microangiopathy.Circulation reports · 2026Article
- Long-Term Survival Following Nivolumab Treatment in Pulmonary Tumour Thrombotic Microangiopathy Associated With Cancer of Unknown Primary: A Case Report.Respirology case reports · 2026Article
- Pulmonary tumor thrombotic microangiopathy associated with prostate cancer achieving over 10-year survival: a case report.International cancer conference journal · 2026Article
- Article
- Tumoural emboli syndromes case series: diagnostic dilemma in patients with cancer and pulmonary hypertension.European heart journal. Case reports · 2026Article
- Right-sided cardiogenic shock from acute pulmonary tumor thrombotic microangiopathy: a rare but deadly cardio-oncologic and metabolic emergency.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Article
- Breast Cancer Reveals LatentCirculation · 2026Article
- Pulmonary Tumor Thrombotic Microangiopathy in a Patient With Male Breast Cancer: A Report of a Rare Case.Cureus · 2026Article
- Construction and validation of a prediction model for malignant pulmonary nodules based on imaging, demographic, and laboratory features.Frontiers in oncology · 2026Article
- Pulmonary tumour thrombotic microangiopathy or chronic thromboembolic pulmonary hypertension?-diagnosed by pulmonary wedge aspiration cytology using a Swan-Ganz catheter: a case report.European heart journal. Case reports · 2026Article
- Bridging via extracorporeal cardiopulmonary resuscitation for hemodynamic collapse in a patient with metastatic lung cancer: a case report.JA clinical reports · 2025Article
- Pulmonary Tumor Thrombotic Microangiopathy in Platinum-Resistant Ovarian Cancer - A Case Report.Acta Cardiologica Sinica · 2025Article
- Non-thrombotic pulmonary emboli: imaging findings and differential diagnoses.Japanese journal of radiology · 2025Review
- Integrative AI-metabolomics: a new frontier in diagnosing pulmonary tumor thrombotic microangiopathy.Annals of medicine and surgery (2012) · 2025Article
- Pulmonary tumor thrombotic microangiopathy associated with endometrial carcinoma: A case report.Journal of cardiology cases · 2025Article
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- Pulmonary tumour thrombotic microangiopathy: case report of a rare cause of right ventricular acute pressure overload.European heart journal. Case reports · 2025Article
- Dissociation Between Tumor Response and PTTM Progression During Entrectinib Therapy in NTRK Fusion-Positive Colon Cancer.Current oncology (Toronto, Ont.) · 2025Article
- Pulmonary Tumor Thrombotic Microangiopathy Associated With Gastric Cancer: Clinical Characteristics and Outcomes.Journal of gastric cancer · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal disease process in which pulmonary hypertension (PH) develops in the setting of malignancy. The purpose of this study is to present a detailed analysis of cases of PTTM reported in literature in the hopes of achieving more ante-mortem diagnoses. We conducted a systematic review of currently published and available cases of PTTM by searching the term "pulmonary tumor thrombotic microangiopathy" on the Pubmed.gov database. Seventy-nine publications were included consisting of 160 unique cases of PTTM. The most commonly reported malignancy was gastric adenocarcinoma (94 cases, 59%). Cough and dyspnea were reported in 61 (85%) and 102 (94%) cases, respectively. Hypoxemia was reported in 96 cases (95%). Elevation in D-dimer was noted in 36 cases (95%), presence of anemia in 32 cases (84%), and thrombocytopenia in 30 cases (77%). Common findings on chest computed tomography (CT) included ground-glass opacities (GGO) in 28 cases (82%) and nodules in 24 cases (86%). PH on echocardiography was noted in 59 cases (89%) with an average right ventricular systolic pressure of 71 mmHg. Common features of PTTM that are reported across the published literature include presence of dyspnea and cough, hypoxemia, with abnormal CT findings of GGO, nodules, and mediastinal/hilar lymphadenopathy, and PH. PTTM is a universally fatal disease process and this analysis provides a detailed examination of all the available published data that may help clinicians establish an earlier diagnosis of PTTM.
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