Evidence map›Paper›PMID 31032472›Full record

ArticleJCO precision oncology2019

Genomic Assessment of Blood-Derived Circulating Tumor DNA in Patients With Colorectal Cancers: Correlation With Tissue Sequencing, Therapeutic Response, and Survival.

Shumei Kato, Maria C Schwaederlé, Paul T Fanta, Ryosuke Okamura, Lawrence Leichman, Scott M Lippman, Richard B Lanman, Victoria M Raymond, AmirAli Talasaz, Razelle Kurzrock

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCO precision oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Concordance between Tumor Tissue and Plasma DNA Genotyping in the NCI-MATCH Trial (EAY131).Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  8. ctDNA Analysis in ERBB2-Amplified Colorectal Cancer: Biomarker Analysis of the MyPathway Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  9. Article
  10. The Landscape of ctDNA in Appendiceal Adenocarcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shumei Kato *Shumei Kato, Maria C. Schwaederlé, Paul T. Fanta, Ryosuke Okamura, Lawrence Leichman, and Scott M. Lippman, Razelle Kurzrock, University of California San Diego Moores Cancer Center, La Jolla; and Richard B. Lanman, Victoria M. Raymond, and AmirAli Talasaz, Guardant Health, Redwood City, CA.
Maria C Schwaederlé *Shumei Kato, Maria C. Schwaederlé, Paul T. Fanta, Ryosuke Okamura, Lawrence Leichman, and Scott M. Lippman, Razelle Kurzrock, University of California San Diego Moores Cancer Center, La Jolla; and Richard B. Lanman, Victoria M. Raymond, and AmirAli Talasaz, Guardant Health, Redwood City, CA.
Paul T FantaShumei Kato, Maria C. Schwaederlé, Paul T. Fanta, Ryosuke Okamura, Lawrence Leichman, and Scott M. Lippman, Razelle Kurzrock, University of California San Diego Moores Cancer Center, La Jolla; and Richard B. Lanman, Victoria M. Raymond, and AmirAli Talasaz, Guardant Health, Redwood City, CA.
Ryosuke OkamuraShumei Kato, Maria C. Schwaederlé, Paul T. Fanta, Ryosuke Okamura, Lawrence Leichman, and Scott M. Lippman, Razelle Kurzrock, University of California San Diego Moores Cancer Center, La Jolla; and Richard B. Lanman, Victoria M. Raymond, and AmirAli Talasaz, Guardant Health, Redwood City, CA.
Lawrence LeichmanShumei Kato, Maria C. Schwaederlé, Paul T. Fanta, Ryosuke Okamura, Lawrence Leichman, and Scott M. Lippman, Razelle Kurzrock, University of California San Diego Moores Cancer Center, La Jolla; and Richard B. Lanman, Victoria M. Raymond, and AmirAli Talasaz, Guardant Health, Redwood City, CA.
Scott M LippmanShumei Kato, Maria C. Schwaederlé, Paul T. Fanta, Ryosuke Okamura, Lawrence Leichman, and Scott M. Lippman, Razelle Kurzrock, University of California San Diego Moores Cancer Center, La Jolla; and Richard B. Lanman, Victoria M. Raymond, and AmirAli Talasaz, Guardant Health, Redwood City, CA.
Richard B LanmanShumei Kato, Maria C. Schwaederlé, Paul T. Fanta, Ryosuke Okamura, Lawrence Leichman, and Scott M. Lippman, Razelle Kurzrock, University of California San Diego Moores Cancer Center, La Jolla; and Richard B. Lanman, Victoria M. Raymond, and AmirAli Talasaz, Guardant Health, Redwood City, CA.
Victoria M RaymondShumei Kato, Maria C. Schwaederlé, Paul T. Fanta, Ryosuke Okamura, Lawrence Leichman, and Scott M. Lippman, Razelle Kurzrock, University of California San Diego Moores Cancer Center, La Jolla; and Richard B. Lanman, Victoria M. Raymond, and AmirAli Talasaz, Guardant Health, Redwood City, CA.
AmirAli TalasazShumei Kato, Maria C. Schwaederlé, Paul T. Fanta, Ryosuke Okamura, Lawrence Leichman, and Scott M. Lippman, Razelle Kurzrock, University of California San Diego Moores Cancer Center, La Jolla; and Richard B. Lanman, Victoria M. Raymond, and AmirAli Talasaz, Guardant Health, Redwood City, CA.
Razelle KurzrockShumei Kato, Maria C. Schwaederlé, Paul T. Fanta, Ryosuke Okamura, Lawrence Leichman, and Scott M. Lippman, Razelle Kurzrock, University of California San Diego Moores Cancer Center, La Jolla; and Richard B. Lanman, Victoria M. Raymond, and AmirAli Talasaz, Guardant Health, Redwood City, CA.

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
NCI NIH HHS P30 CA023100
6 · The paper itself

Abstract

purposeGenomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with colorectal cancers were correlated with clinical outcomes. PATIENTS AND

methodsNext-generation sequencing of ctDNA (54- to 73-gene panel) was performed in 94 patients with colorectal cancer.

resultsMost patients (96%) had metastatic or recurrent disease at the time of blood draw. The median number of nonsynonymous alterations per patient was three (range, zero to 30). The most frequently aberrant genes were

conclusionPatients with colorectal cancer have heterogeneous ctDNA profiles, and most harbor potentially actionable ctDNA alterations. Matched therapy yielded higher rates of stable disease for 6 months or more, partial response, or complete response. ctDNA assessment may have clinical utility and merits further investigation.

Identifiers

PMID31032472
PMCPMC6484865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.