ArticleScience advances2019
WindSTORM: Robust online image processing for high-throughput nanoscopy.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Automated Cyclic Super-Resolution Microscopy for Nanoscale Protein Mapping.bioRxiv : the preprint server for biology · 2026Article
- Ultrafast and specific miRNA quantification via single-molecule fluorescence quenching kinetics.Communications biology · 2026Article
- Optical super-resolution histology of formalin-fixed paraffin-embedded tissue samples: challenges and opportunities.Nature communications · 2025Review
- Fortunate molecules boost signal to background ratio and localization precision in correlation based single molecule localization microscopy.Communications biology · 2024Article
- An Omni-Mesoscope for multiscale high-throughput quantitative phase imaging of cellular dynamics and high-content molecular characterization.Science advances · 2024Article
- Toward drift-free high-throughput nanoscopy through adaptive intersection maximization.Science advances · 2024Article
- Near-infrared PAINT localization microscopy via chromophore replenishment of phytochrome-derived fluorescent tag.Communications biology · 2024Article
- RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.The journal of physical chemistry. B · 2024Article
- Scanning single molecule localization microscopy (scanSMLM) for super-resolution volume imaging.Communications biology · 2023Article
- Nanoscale imaging of CD47 informs how plasma membrane modifications shape apoptotic cell recognition.Communications biology · 2023Article
- Particle Localization Using Local Gradients and Its Application to Nanometer Stabilization of a Microscope.ACS nano · 2022Article
- PCIe-based FPGA-GPU heterogeneous computation for real-time multi-emitter fitting in super-resolution localization microscopy.Biomedical optics express · 2022Article
- Enhanced super-resolution microscopy by extreme value based emitter recovery.Scientific reports · 2021Article
- Estimating the dynamic range of quantitative single-molecule localization microscopy.Biophysical journal · 2021Article
- Embedded nanometer position tracking based on enhanced phasor analysis.Optics letters · 2021Article
- Probing Chromatin Compaction and Its Epigenetic StatesFrontiers in cell and developmental biology · 2021Review
- Optimized Stochastic Optical Reconstruction Microscopy for Imaging Chromatin Structure in Pathological Tissue.Current protocols in cytometry · 2020Article
- Potential quality improvement of stochastic optical localization nanoscopy images obtained by frame by frame localization algorithms.Scientific reports · 2020Article
- Super-resolution Surface-Enhanced Raman Scattering Imaging of Single Particles in Cells.Analytical chemistry · 2020Article
- Super-resolution localization microscopy: Toward high throughput, high quality, and low cost.APL photonics · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
High-throughput nanoscopy becomes increasingly important for unraveling complex biological processes from a large heterogeneous cell population at a nanoscale resolution. High-density emitter localization combined with a large field of view and fast imaging frame rate is commonly used to achieve a high imaging throughput, but the image processing speed and the presence of heterogeneous background in the dense emitter scenario remain a bottleneck. Here, we present a simple non-iterative approach, referred to as WindSTORM, to achieve high-speed high-density emitter localization with robust performance for various image characteristics. We demonstrate that WindSTORM improves the computation speed by two orders of magnitude on CPU and three orders of magnitude upon GPU acceleration to realize online image processing, without compromising localization accuracy. Further, WindSTORM is highly robust to maximize the localization accuracy and minimize the image artifacts in the presence of nonuniform background. WindSTORM paves the way for next generation high-throughput nanoscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.