ArticleScience advances2019
RUNX represses
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis.Oncogene · 2023Article
- Inhibition of YAP Sensitizes the Selumetinib Treatment for Neurofibromatosis Type 1 Related Plexiform Neurofibroma.International journal of medical sciences · 2023Article
- Muscle Regeneration in Holothurians without the Upregulation of Muscle Genes.International journal of molecular sciences · 2022Article
- Review
- Pharmacological Approaches in Neurofibromatosis Type 1-Associated Nervous System Tumors.Cancers · 2021Review
- Article
- The Role of RUNX1 in NF1-Related Tumors and Blood Disorders.Molecules and cells · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 5 institutions in 2 countries.
Ashley HallCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.ORCID 0000-0002-7982-1025
Kwangmin ChoiCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.ORCID 0000-0003-4671-962X
Wei LiuCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Jonathan RoseCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Chuntao ZhaoCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Yanan YuCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Youjin NaCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Yuqi CaiCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Robert A CooverCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Yi LinCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Eva DombiPediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
MiOk KimDepartment of Epidemiology and Biostatistics, UCSF, Box 0128, 1450 3rd St. Suite 285, San Francisco, CA 94143, USA.ORCID 0000-0002-7712-3653
Ditsa LevanonDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-0376-4466
Yoram GronerDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Elisa BoscoloCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Dao PanCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.ORCID 0000-0003-2433-0285
P Paul LiuNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Q Richard LuCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Nancy RatnerCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Gang HuangCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Jianqiang WuCincinnati Children's Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, University of Cincinnati, 3333 Burnet Ave., Cincinnati, OH 45229, USA.ORCID 0000-0002-4239-5659
Cincinnati Children's Hospital Medical Center · USWeizmann Institute of Science · ILNational Cancer Institute · USNational Institutes of Health · USUniversity of California, San Francisco · US
Funding
MOLECULAR PATHOGENESIS OF CHROMOSOME 16 INVERSION INHUMAN LEUKEMIAZIAHG000030 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI LIU, PAUL · 2009 to 2025
$15.8MMiR-155 and RUNX function in neurofibroma tumorigenesis and therapyR01NS097233 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI Jianqiang Wu · 2016 to 2026
$3.8MMolecular Mechanisms of Oligodendrocyte Differentiation and MyelinationR01NS072427 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI LU, QING R · 2010 to 2018
$3.6MRas Proteins in Nerve TumorigensisR37NS083580 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI RATNER, NANCY · 2014 to 2020
$2.7MChromatin remodeling control of myelination and remyelinationR01NS075243 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI LU, QING R · 2012 to 2018
$2.6MMolecular and signaling mechanisms of peripheral nerve sheath tumorigenesisR37NS096359 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI LU, QING R · 2016 to 2018
$1.6MNINDS NIH HHS R01 NS072427NINDS NIH HHS R01 NS075243NINDS NIH HHS R01 NS097233NINDS NIH HHS R37 NS083580NINDS NIH HHS R37 NS096359
Abstract
Patients with neurofibromatosis type 1 (NF1) are predisposed to develop neurofibromas, but the underlying molecular mechanisms of neurofibromagenesis are not fully understood. We showed dual genetic deletion of
Indexed as
Gene Expression Regulation, NeoplasticAllelesAnimalsBase SequenceCell ProliferationCell SurvivalCore Binding Factor Alpha 2 SubunitCore Binding Factor Alpha 3 SubunitCore Binding Factor beta SubunitFemaleGene DeletionHumansMaleMiceMice, NudeMyelin ProteinsCBFB protein, humanCbfb protein, mouseCore Binding Factor Alpha 2 SubunitCore Binding Factor Alpha 3 SubunitCore Binding Factor beta SubunitMyelin ProteinsPMP22 protein, humanPmp22 protein, mouseRNA, Small InterferingRUNX1 protein, humanRunx1 protein, mouseRunx3 protein, humanRunx3 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.