ArticleCurrent opinion in behavioral sciences2018
The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration.
Article in Current opinion in behavioral sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebral Volumetric Correlates of Apathy in Alzheimer's Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort.Journal of Alzheimer's disease : JAD · 2022Pooled it
- Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.PLoS computational biology · 2022Trial
- The relationship between apathy and impulsivity in large population samples.Scientific reports · 2021Trial
- Decision context and neurobehavioural disturbance in Huntington's disease.Cognitive, affective & behavioral neuroscience · 2026Article
- Revisiting the relationship between impulsivity, apathy, and action control: Bayesian inference from a stop-signal task study.PloS one · 2026Article
- Article
- Association of Menstrual Cycle with Fronto-Striatal Connectivity and Delay Discounting.Behavioral sciences (Basel, Switzerland) · 2025Article
- Article
- Monoamine alterations in Alzheimer's disease and their implications in comorbid neuropsychiatric symptoms.GeroScience · 2025Review
- Apathy and Impulsivity Co-Occur in Huntington's Disease.Brain and behavior · 2024Article
- A neuroanatomical and cognitive model of impaired social behaviour in frontotemporal dementia.Brain : a journal of neurology · 2024Review
- Impaired value-based decision-making in Parkinson's disease apathy.Brain : a journal of neurology · 2024Article
- A narrative review on mild behavioural impairment: an exploration into its scientific perspectives.Aging clinical and experimental research · 2023Review
- Elevated representational similarity of voluntary action and inhibition in Tourette syndrome.Brain communications · 2023Article
- Evaluation of risk factors for impulse control disorder in Parkinson's disease in northern China.Frontiers in aging neuroscience · 2023Article
- Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Disordered Decision Making: A Cognitive Framework for Apathy and Impulsivity in Huntington's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Virtual Reality Intervention for Managing Apathy in People With Cognitive Impairment: Systematic Review.JMIR aging · 2022Review
- Prefrontal Cortical Connectivity Mediates Locus Coeruleus Noradrenergic Regulation of Inhibitory Control in Older Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Evidence and implications of abnormal predictive coding in dementia.Brain : a journal of neurology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Apathy and impulsivity are common and often coexistent consequences of frontotemporal lobar degeneration (FTLD). They increase patient morbidity and carer distress, but remain under-estimated and poorly treated. Recent trans-diagnostic approaches that span the spectrum of clinical presentations of FTLD and parkinsonism, indicate that apathy and impulsivity can be fractionated into multiple neuroanatomical and pharmacological systems. These include ventral/dorsal fronto-striatal circuits for reward-sensitivity, response-inhibition, and decision-making; moderated by noradrenaline, dopamine, and serotonin. Improved assessment tools, formal models of cognition and behavior, combined with brain imaging and psycho-pharmacology, are creating new therapeutic targets and establishing principles for stratification in future clinical trials.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.