Evidence map›Paper›PMID 31032369›Full record

ArticleBioMed research international2019

Calcium Dyshomeostasis Alters CCL5 Signaling in Differentiated PC12 Cells.

Tomasz Radzik, Tomasz Boczek, Bozena Ferenc, Maciej Studzian, Lukasz Pulaski, Ludmila Zylinska

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. The Puzzling Role of Neuron-Specific PMCA Isoforms in the Aging Process.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Tomasz RadzikDepartment of Molecular Neurochemistry, Medical University, 6/8 Mazowiecka Str., 92-215 Lodz, Poland.
Tomasz BoczekDepartment of Molecular Neurochemistry, Medical University, 6/8 Mazowiecka Str., 92-215 Lodz, Poland.ORCID 0000-0002-7654-9011
Bozena FerencDepartment of Molecular Neurochemistry, Medical University, 6/8 Mazowiecka Str., 92-215 Lodz, Poland.
Maciej StudzianDepartment of Molecular Biophysics, University of Lodz, 12/16 Banacha Str., 90-237 Lodz, Poland.
Lukasz PulaskiDepartment of Molecular Biophysics, University of Lodz, 12/16 Banacha Str., 90-237 Lodz, Poland.
Ludmila ZylinskaDepartment of Molecular Neurochemistry, Medical University, 6/8 Mazowiecka Str., 92-215 Lodz, Poland.ORCID 0000-0002-3876-8942
Medical University of Lodz · PLUniversity of Łódź · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlasma membrane Ca

methodsTo mimic the changes in aged neurons we used stable transfected differentiated PC12 cells with downregulated PMCA2 or PMCA3 and analyzed the effect of CCL5 on calcium transients with Fluo-4 reagent. Chemokine receptors were evaluated using Western blot, and IP

resultsIn PMCA-reduced cell lines, CCL5 released more Ca

conclusionAlthough modification of PMCAs composition could provide some protection against calcium overload, reduction of PMCA2 appeared to be more detrimental to the cells than deficiency of PMCA3. Under pathological conditions, including inflammatory CCL5 action and long-lasting Ca

Indexed as

Aniline CompoundsAnimalsBrainCalciumCalcium SignalingCell DeathCell DifferentiationCell MembraneChemokine CCL5HomeostasisHumansNeuronsPC12 CellsPlasma Membrane Calcium-Transporting ATPasesRatsSignal TransductionAniline CompoundsAtp2b2 protein, ratAtp2b3 protein, ratCalciumChemokine CCL5Fluo 4Plasma Membrane Calcium-Transporting ATPasesXanthenes

Identifiers

PMID31032369
PMCPMC6457283
OpenAlexW2923048557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.