ReviewFrontiers in cell and developmental biology2019
The Expression and Possible Functions of Tenascin-W During Development and Disease.
Review in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Identification of a new population of TnnBone research · 2026Article
- Increased TNN in Knee Osteoarthritis Accelerates Cartilage Damage via the Negative Regulation of AMPK-PPARγ Signalling.Journal of cellular and molecular medicine · 2025Article
- Transcriptomic Profiling of Mouse Mesenchymal Stem Cells Exposed to Metal-Based Nanoparticles.International journal of molecular sciences · 2025Article
- Article
- The evolution of tenascins.BMC ecology and evolution · 2024Article
- Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application.Bioactive materials · 2024Review
- Single-cell RNA sequencing analysis of the temporomandibular joint condyle in 3 and 4-month-old human embryos.Cell & bioscience · 2023Article
- Integrated spatiotemporal transcriptomic resolution of embryonic palate osteogenesis.bioRxiv : the preprint server for biology · 2023Article
- Gene expression analysis of the Xenopus laevis early limb bud proximodistal axis.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- The profiling and analysis of gene expression in human periodontal ligament tissue and fibroblasts.Clinical and experimental dental research · 2022Article
- Article
- Revisiting the Tenascins: Exploitable as Cancer Targets?Frontiers in oncology · 2022Review
- Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression.International journal of molecular sciences · 2021Review
- Did Tenascin-C Co-Evolve With the General Immune System of Vertebrates?Frontiers in immunology · 2021Review
- Latent TGF-β Activation Is a Hallmark of the Tenascin Family.Frontiers in immunology · 2021Article
- Mapping the Inorganic and Proteomic Differences among Different Types of Human Teeth: A Preliminary Compositional Insight.Biomolecules · 2020Article
- Emerging Roles of Matricellular Proteins in Systemic Sclerosis.International journal of molecular sciences · 2020Review
- Loss of Tenascin-X expression during tumor progression: A new pan-cancer marker.Matrix biology plus · 2020Article
- Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers.Frontiers in immunology · 2020Article
- Tenascin-W: Discovery, Evolution, and Future Prospects.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tenascins are a family of multifunctional glycoproteins found in the extracellular matrix of chordates. Two of the tenascins, tenascin-C and tenascin-W, form hexabrachions. In this review, we describe the discovery and domain architecture of tenascin-W, its evolution and patterns of expression during embryogenesis and in tumors, and its effects on cells in culture. In avian and mammalian embryos tenascin-W is primarily expressed at sites of osteogenesis, and in the adult tenascin-W is abundant in certain stem cell niches. In primary cultures of osteoblasts tenascin-W promotes cell migration, the formation of mineralized foci and increases alkaline phosphatase activity. Tenascin-W is also prominent in many solid tumors, yet it is missing from the extracellular matrix of most adult tissues. This makes it a potential candidate for use as a marker of tumor stroma and a target for anti-cancer therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.