ArticleQuantitative imaging in medicine and surgery2019
Intravoxel incoherent motion derived liver perfusion/diffusion readouts can be reliable biomarker for the detection of viral hepatitis B induced liver fibrosis.
Article in Quantitative imaging in medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 34 citations in OpenAlex.
- High-Resolution IVIM MRI Characterizes Diffusion-Perfusion Properties of the Parasagittal Dura.NMR in biomedicine · 2026Article
- Fast, Robust T2-IVIM Quantitative MRI With Distortion and Motion-Corrected Multi-Echo EPI.Magnetic resonance in medicine · 2026Article
- A New Approach for Estimating Liver IVIM Fast Diffusion Coefficient in Two-Compartment Model and Fast Diffusion Fraction in Three-Compartment Model: Theory and In Vivo Validation of Two Centers' Data.NMR in biomedicine · 2026Article
- Current Update on DWI-MRI and Its Radiomics in Liver Fibrosis-A Review of the Literature.Tomography (Ann Arbor, Mich.) · 2025Review
- Monoexponential and advanced diffusion-weighted imaging for hepatic fibrosis staging based on high inter-examiner reliability.Saudi medical journal · 2024Article
- Intravoxel incoherent motion assessment of liver fibrosis staging in MASLD.Abdominal radiology (New York) · 2024Article
- Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models.World journal of gastroenterology · 2024Article
- Article
- Advances in application of novel magnetic resonance imaging technologies in liver disease diagnosis.World journal of gastroenterology · 2023Review
- Multiparametric MRI combined with liver volume for quantitative evaluation of liver function in patients with cirrhosis.Diagnostic and interventional radiology (Ankara, Turkey) · 2022Article
- Bi-exponential fitting excludingQuantitative imaging in medicine and surgery · 2022Article
- More promising results of liver intravoxel incoherent motion imaging analysis for the assessment of nonalcoholic steatohepatitis and fibrosis.Annals of translational medicine · 2021Article
- Mutual constraining of slow component and fast component measures: some observations in liver IVIM imaging.Quantitative imaging in medicine and surgery · 2021Article
- Three-dimensional pulsed continuous arterial spin labeling and intravoxel incoherent motion imaging of nasopharyngeal carcinoma: correlations with Ki-67 proliferation status.Quantitative imaging in medicine and surgery · 2021Article
- Evidence of Tri-Exponential Decay for Liver Intravoxel Incoherent Motion MRI: A Review of Published Results and Limitations.Diagnostics (Basel, Switzerland) · 2021Review
- Diffusion-weighted MRI of the liver: challenges and some solutions for the quantification of apparent diffusion coefficient and intravoxel incoherent motion.American journal of nuclear medicine and molecular imaging · 2021Review
- Collagen deposition in the liver is strongly and positively associated with T1rho elongation while fat deposition is associated with T1rho shortening: an experimental study of methionine and choline-deficient (MCD) diet rat model.Quantitative imaging in medicine and surgery · 2020Article
- Quantitative assessment of renal allograft pathologic changes: comparisons of mono-exponential and bi-exponential models using diffusion-weighted imaging.Quantitative imaging in medicine and surgery · 2020Article
- Topics on quantitative liver magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2019Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent two studies reported that intravoxel incoherent motion (IVIM) analysis can separate healthy livers and viral hepatitis B (VHB) induced liver fibrosis. However, in these two studies the starting
methodsThis was a prospective study with data acquired at the Third Xiangya Hospital of Central South University, Changsha, China. Healthy volunteers and patients suspected of VHB induced liver fibrosis with liver biopsy performed, as well as hepatocellular carcinoma patients scheduled for surgery, were recruited. All the hepatocellular carcinoma patients had liver fibrosis. After exclusions based on pre-defined criteria for image data quality, for IVIM analysis this study included 20 healthy volunteers; 4 chronic VHB patients with biopsy showing no liver fibrosis; 11 stage-1 liver fibrosis patients, 10 stage-2 liver fibrosis patients, 2 stage-3 liver fibrosis patients, and 5 stage-4 liver fibrosis patients. In the liver fibrosis patients, 1, 19, and 8 cases had inflammation grade-0, grade-1, and grade-2 respectively. The reference IVIM bi-exponential decay curve fitting analysis was segmented fitting performed with
resultsBased on the smaller coefficient of variation (CoV) for the volunteer group and the smaller patient/volunteer ratios [= (mean measurement for patient groups)/(mean measurement for healthy volunteers)], the comparison of fitting methods favored the reference approach starting from
conclusionsSegmented-fitting with threshold-
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