Evidence map›Paper›PMID 31032133›Full record

ArticleCase reports in pathology2019

An Unusual Hybrid Salivary Gland Tumor: Molecular Analysis Informs the Potential Pathogenesis of This Rare Neoplasm.

Yan Zhou, Ernesto Martinez Duarte, David J Eleff, Laura J Tafe, Jason M Leibowitz, Darcy A Kerr

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PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yan ZhouDepartment of Pathology and Laboratory Medicine, University of Miami/Jackson Memorial Hospital and Miller School of Medicine, Miami, FL, USA.ORCID 0000-0002-9867-5828
Ernesto Martinez DuarteDepartment of Pathology and Laboratory Medicine, University of Miami/Jackson Memorial Hospital and Miller School of Medicine, Miami, FL, USA.
David J EleffDepartment of Otolaryngology Division of Head and Neck Surgery, University of Miami/Jackson Memorial Hospital and Miller School of Medicine, Miami, FL, USA.
Laura J TafeDepartment of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Jason M LeibowitzDepartment of Otolaryngology Division of Head and Neck Surgery, University of Miami/Jackson Memorial Hospital and Miller School of Medicine, Miami, FL, USA.
Darcy A KerrDepartment of Pathology and Laboratory Medicine, University of Miami/Jackson Memorial Hospital and Miller School of Medicine, Miami, FL, USA.ORCID 0000-0002-3228-2044

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe presence of two or more tumor entities growing in adjacent locations within the salivary gland is very rare, and pathologic studies on such lesions are limited, particularly those with molecular information. Since the clinical history and imaging studies are usually nonspecific, accurate diagnosis and clinical management largely depend on a thorough histological examination. METHODS AND

resultsWe describe a 71-year-old man with an unusual case of hybrid salivary gland tumor composed of mucoepidermoid carcinoma and basal cell adenoma. Molecular analysis revealed differing driver genetic alterations in each component.

conclusionsHybrid salivary gland tumors are rare, and their pathogenesis is controversial. The combination of mucoepidermoid carcinoma and basal cell adenoma has not been previously described. While malignant transformation of adenoma to carcinoma seems plausible, gene sequencing was more suggestive of their independent derivation. Key to appropriate surgical management is identifying the more aggressive component, ideally at the time of intraoperative consultation.

Identifiers

PMID31032133
PMCPMC6458882

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