Evidence map›Paper›PMID 31031905›Full record

ArticleChemical science2013

Glycomimetic affinity-enrichment proteomics identifies partners for a clinically-utilized iminosugar.

Isa N Cruz, Conor S Barry, Holger B Kramer, C Celeste Chuang, Sarah Lloyd, Aarnoud C van der Spoel, Frances M Platt, Min Yang, Benjamin G Davis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Identification ofThe Journal of biological chemistry · 2018
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isa N Cruz *Department of Pharmaceutical & Biological Chemistry, UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London, WC1N 1AX, UK.
Conor S Barry *Department of Chemistry, Chemistry Research Laboratory, Oxford University, Mansfield Road, Oxford, OX1 3TA, UK.
Holger B KramerDepartment of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3PT, UK.
C Celeste ChuangDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Sarah LloydMRC Prion Unit, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Aarnoud C van der SpoelDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Frances M PlattDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
Min YangDepartment of Pharmaceutical & Biological Chemistry, UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London, WC1N 1AX, UK.
Benjamin G DavisDepartment of Chemistry, Chemistry Research Laboratory, Oxford University, Mansfield Road, Oxford, OX1 3TA, UK.

Funding

Biotechnology and Biological Sciences Research Council BB/E004350/1Biotechnology and Biological Sciences Research Council EGA17763Medical Research Council MC_U123160652Wellcome Trust 084655
6 · The paper itself

Abstract

Widescale evaluation of interacting partners for carbohydrates is an underexploited area. Probing of the 'glyco-interactome' has particular relevance given the lack of direct genetic control of glycoconjugate biosynthesis. Here we design, create and utilize a natural product-derived glycomimetic iminosugar probe in a Glycomimetic Affinity-enrichment Proteomics (glyco-A

Identifiers

PMID31031905
PMCPMC6485602

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.