ArticleBasic and clinical neuroscience
Characterization of Functional Effects of Two New Active Fractions Isolated From Scorpion Venom on Neuronal Ca
Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors at 5 institutions in 3 countries.
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Abstract
introductionIt is a long time that natural toxin research is conducted to unlock the medical potential of toxins. Although venoms-toxins cause pathophysiological conditions, they may be effective to treat several diseases. Since toxins including scorpion toxins target voltage-gated ion channels, they may have profound effects on excitable cells. Therefore, elucidating the cellular and electrophysiological impacts of toxins, particularly scorpion toxins would be helpful in future drug development opportunities.
methodsIntracellular recording was made from F1 cells of Helix aspersa in the presence of calcium Ringer solution in which Na
resultsThe two active toxin fractions, similar to KTX, a known Ca
conclusionThese toxin fractions may act as blocker of calcium-activated potassium channels.
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