ReviewBasic and clinical neuroscience
Dopaminergic Modulation of Synaptic Plasticity, Its Role in Neuropsychiatric Disorders, and Its Computational Modeling.
Review in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 48 citations in OpenAlex.
- Contribution of Glutamatergic and GABAergic Mechanisms to the Plasticity-Modulating Effects of Dopamine in the Human Motor Cortex.Human brain mapping · 2025Trial
- Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture.Molecular psychiatry · 2026Article
- Altered Excitation-Inhibition Balance and mGluRInternational journal of molecular sciences · 2026Article
- TREM2 in neurodegeneration and diseases.Molecular psychiatry · 2026Review
- Photostimulation of locus coeruleus CA1 catecholaminergic terminals reversed Spatial memory impairment in an alzheimer's disease mouse model.Psychopharmacology · 2026Article
- Analysis of clinical trials on drugs targeting dopamine receptors: a scoping review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Tyrosine Hydroxylase-Expressing Neurons in the Vagal Ganglia: Characterization and Implications.Biomedicines · 2025Article
- Computational Neuroscience's Influence on Autism Neuro-Transmission Research: Mapping Serotonin, Dopamine, GABA, and Glutamate.Biomedicines · 2025Review
- Synaptic Interactions Between Serotonergic and Dopaminergic Systems in Parkinson's Disease.Current neuropharmacology · 2025Review
- Sex-Specific Mechanisms Underlie Long-Term Potentiation at Hippocampus→Medium Spiny Neuron Synapses in the Medial Shell of the Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Decoding visual evoked potential latency: revealing neurological connections in Parkinson's disease.Journal of medicine and life · 2024Observational
- Chronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway.Experimental & molecular medicine · 2024Article
- Methylphenidate Ameliorates Behavioural and Neurobiological Deficits in Executive Function for Patients with Chronic Traumatic Brain Injury.Journal of clinical medicine · 2024Article
- Current Review of the Function and Regulation of Tuberoinfundibular Dopamine Neurons.International journal of molecular sciences · 2023Review
- Reactive Oxygen Species Mediate Transcriptional Responses to Dopamine and Cocaine in Human Cerebral Organoids.International journal of molecular sciences · 2023Article
- Bidirectional mechanism of comorbidity of depression and insomnia based on synaptic plasticity.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Anxiety and depression: A top-down, bottom-up model of circuit function.Annals of the New York Academy of Sciences · 2023Review
- Delay-dependent transitions of phase synchronization and coupling symmetry between neurons shaped by spike-timing-dependent plasticity.Cognitive neurodynamics · 2023Article
- Association of Cognitive Deficit with Glutamate and Insulin Signaling in a Rat Model of Parkinson's Disease.Biomedicines · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuromodulators modify intrinsic characteristics of the nervous system in order to reconfigure the functional properties of neural circuits. This reconfiguration is crucial for the flexibility of the nervous system to respond on an input-modulated basis. Such a functional rearrangement is realized by modification of intrinsic properties of the neural circuits including synaptic interactions. Dopamine is an important neuromodulator involved in motivation and stimulus-reward learning process, and adjusts synaptic dynamics in multiple time scales through different pathways. The modification of synaptic plasticity by dopamine underlies the change in synaptic transmission and integration mechanisms, which affects intrinsic properties of the neural system including membrane excitability, probability of neurotransmitters release, receptors' response to neurotransmitters, protein trafficking, and gene transcription. Dopamine also plays a central role in behavioral control, whereas its malfunction can cause cognitive disorders. Impaired dopamine signaling is implicated in several neuropsychiatric disorders such as Parkinson's disease, drug addiction, schizophrenia, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder and Tourette's syndrome. Therefore, dopamine plays a crucial role in the nervous system, where its proper modulation of neural circuits may enhance plasticity-related procedures, but disturbances in dopamine signaling might be involved in numerous neuropsychiatric disorders. In recent years, several computational models are proposed to formulate the involvement of dopamine in synaptic plasticity or neuropsychiatric disorders and address their connection based on the experimental findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.