Evidence map›Paper›PMID 31031746›Full record

ArticleFrontiers in immunology2019

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG.

Arianne M Brandsma, Sina Bondza, Mitchell Evers, Rosanne Koutstaal, Maaike Nederend, J H Marco Jansen, Thies Rösner, Thomas Valerius, Jeanette H W Leusen, Toine Ten Broeke

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 140 citations in OpenAlex.

  1. Trial
  2. Review
  3. Neutrophils in cancer.Nature reviews. Cancer · 2026
    Review
  4. Article
  5. Humoral immunity in cancer.Signal transduction and targeted therapy · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
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  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Target neutrophil heterogeneity and plasticity in cancer.Journal of hematology & oncology · 2025
    Review

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Arianne M BrandsmaLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Sina BondzaRidgeview Instruments AB, Vänge, Sweden.
Mitchell EversLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Rosanne KoutstaalLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Maaike NederendLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
J H Marco JansenLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Thies RösnerDivision of Stem Cell Transplantation and Immunotherapy, Department of Internal Medicine II, Christian-Albrechts-University, Kiel, Germany.
Thomas ValeriusDivision of Stem Cell Transplantation and Immunotherapy, Department of Internal Medicine II, Christian-Albrechts-University, Kiel, Germany.
Jeanette H W LeusenLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
Toine Ten BroekeLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
University Medical Center Utrecht · NLKiel University · DEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibody therapy of cancer is increasingly used in the clinic and has improved patient's life expectancy. Except for immune checkpoint inhibition, the mode of action of many antibodies is to recognize overexpressed or specific tumor antigens and initiate either direct F(ab')

Indexed as

Antibody-Dependent Cell CytotoxicityCell DeathCell Line, TumorHumansImmunoglobulin AImmunoglobulin GImmunotherapyModels, ImmunologicalNeoplasmsNeutrophilsReceptors, FcSignal TransductionImmunoglobulin AImmunoglobulin GReceptors, FcADCCcancerCD89Fc alpha receptor IIgAimmunotherapyneutrophilsignaling

Identifiers

PMID31031746
PMCPMC6470253
OpenAlexW2938405616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.