Evidence map›Paper›PMID 31031722›Full record

ArticleFrontiers in microbiology2019

Potent Inhibition of Zika Virus Replication by Aurintricarboxylic Acid.

Jun-Gyu Park, Ginés Ávila-Pérez, Ferralita Madere, Thomas A Hilimire, Aitor Nogales, Fernando Almazán, Luis Martínez-Sobrido

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Therapeutic Use ofAnimals : an open access journal from MDPI · 2025
    Article
  2. Review
  3. Acta biochimica et biophysica Sinica · 2025
    Article
  4. Reverse Genetics of Zika Virus Using a Bacterial Artificial Chromosome.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The Dual Regulation of Apoptosis by Flavivirus.Frontiers in microbiology · 2021
    Review
  13. Inhibition of Orbivirus Replication by Aurintricarboxylic Acid.International journal of molecular sciences · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jun-Gyu ParkDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Ginés Ávila-PérezDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Ferralita MadereDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Thomas A HilimireDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Aitor NogalesCenter for Animal Health Research, INIA-CISA, Madrid, Spain.
Fernando AlmazánDepartment of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.
Luis Martínez-SobridoDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
University of Rochester Medical Center · USCentre de Recerca en Sanitat Animal · ESUniversidad Autónoma de Madrid · ES

Funding

Single-cycle infectious Zika viruses for the development of a live-attenuated vaccineR21AI130500 · NIAID · UNIVERSITY OF ROCHESTER · PI MARTINEZ-SOBRIDO, LUIS · 2017 to 2018
$380k
NIAID NIH HHS R21 AI130500
6 · The paper itself

Abstract

Zika virus (ZIKV) is one of the recently emerging vector-borne viruses in humans and is responsible for severe congenital abnormalities such as microcephaly in the Western Hemisphere. Currently, only a few vaccine candidates and therapeutic drugs are being developed for the treatment of ZIKV infections, and as of yet none are commercially available. The polyanionic aromatic compound aurintricarboxylic acid (ATA) has been shown to have a broad-spectrum antimicrobial and antiviral activity. In this study, we evaluated ATA as a potential antiviral drug against ZIKV replication. The antiviral activity of ATA against ZIKV replication

Indexed as

antiviralsaurintricarboxylic aciddrug treatmentFlavivirusprophylactictherapeuticZika virus

Identifiers

PMID31031722
PMCPMC6473159
OpenAlexW2940239864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.