ArticleFrontiers in neurology2019
Characterizing the Penumbras of White Matter Hyperintensities and Their Associations With Cognitive Function in Patients With Subcortical Vascular Mild Cognitive Impairment.
Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Multimodal MRI markers of white matter hyperintensities and their impact on cognition in cerebral small vessel disease: a systematic review.Brain imaging and behavior · 2026Pooled it
- Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Cerebral "Dirty-Appearing" White Matter in Relation to Cognitive Decline and Dementia Risk in Community-Dwelling Older Adults.Neurology · 2026Article
- Multimodal Magnetic Resonance Imaging Signatures of White Matter Hyperintensities: Mechanistic Insights Into Pathobiological Heterogeneity.Journal of stroke · 2026Review
- Predicting white-matter hyperintensity progression and cognitive decline in patients with cerebral small-vessel disease: a magnetic resonance-based habitat analysis.Quantitative imaging in medicine and surgery · 2024Article
- Association between white matter hyperintensities and altered cerebral blood flow in maintenance hemodialysis patients: a longitudinal study.BMC nephrology · 2024Article
- Associations between cerebral blood flow and progression of white matter hyperintensities.Frontiers in neuroimaging · 2024Article
- Diffusion tensor imaging in cerebral small vessel disease applications: opportunities and challenges.Frontiers in neuroscience · 2024Review
- Characterizing the penumbras of white matter hyperintensities in patients with cerebral small vessel disease.Japanese journal of radiology · 2023Article
- The Relevance of Serum Macrophage Migration Inhibitory Factor Level and Executive Function in Patients with White Matter Hyperintensity in Cerebral Small Vessel Disease.Brain sciences · 2023Article
- The Ties That Bind: Glial Transplantation in White Matter Ischemia and Vascular Dementia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Clinical and cognitive correlates tractography analysis in patients with white matter hyperintensity of vascular origin.Frontiers in neuroscience · 2023Article
- Diffusion tensor free water MRI predicts progression of FLAIR white matter hyperintensities after ischemic stroke.Frontiers in neurology · 2023Article
- Alzheimer's and vascular disease classification using regional texture biomarkers in FLAIR MRI.NeuroImage. Clinical · 2023Article
- Free-water diffusion MRI detects structural alterations surrounding white matter hyperintensities in the early stage of cerebral small vessel disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Brain and cognitive ageing: The present, and some predictions (…about the future).Aging brain · 2022Article
- Characterization of white matter over 1-2 years in small vessel disease using MR-based quantitative susceptibility mapping and free-water mapping.Frontiers in aging neuroscience · 2022Article
- The Enhanced Interhemispheric Functional Connectivity in the Striatum Is Related to the Cognitive Impairment in Individuals With White Matter Hyperintensities.Frontiers in neuroscience · 2022Article
- Fluid-attenuated inversion recovery magnetic resonance imaging textural features as sensitive markers of white matter damage in midlife adults.Brain communications · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal-appearing white matter (NAWM) surrounding white matter hyperintensities (WMHs), frequently known as the WMH penumbra, is associated with subtle white matter injury and has a high risk for future conversion to WMHs. The goal of this study was to define WMH penumbras and to further explore whether the diffusion and perfusion parameters of these penumbras could better reflect cognitive function alterations than WMHs in subjects with subcortical vascular mild cognitive impairment (svMCI). Seventy-three svMCI subjects underwent neuropsychological assessments and 3T MRI scans, including diffusion tensor imaging (DTI) and arterial spin labeling (ASL). To determine the extent of cerebral blood flow (CBF) and DTI penumbras. A NAWM layer mask was generated for periventricular WMHs (PVWMHs) and deep WMHs (DWMHs) separately. Mean values of CBF, fractional anisotropy (FA), mean diffusivity (MD) within the WMHs and their corresponding NAWM layer masks were computed and compared using paired
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