ArticleFrontiers in behavioral neuroscience2019
Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females.
Article in Frontiers in behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed.
- Post-weaning social isolation increases reward-seeking behavior in mice.Physiology & behavior · 2026Article
- Time-Dependent Effects of Neonatal Methamphetamine Exposure on Catecholamines but Not Oxidative Stress in the Hippocampus and Striatum of Male Rats.Neurotoxicity research · 2026Article
- Adolescent social isolation promotes oxycodone consumption and augments mu opioid receptor responsiveness in the ventral pallidum.Addiction neuroscience · 2026Article
- Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner.Brain, behavior, & immunity - health · 2026Article
- Gut microbiota restructured by social isolation: Evidence for sex-specific response patterns.Brain, behavior, & immunity - health · 2026Article
- Oligodendrocyte Egr2 Mediates the Beneficial Effect of Resocialization on the Social Ability of Socially Isolated Mice.Neuroscience bulletin · 2026Article
- Behavioral impact of adolescent social isolation stress: A multidimensional assessment in male NMRI mice.Learning & behavior · 2026Article
- Characterizing Loneliness and Health in US Adults: An analysis of 2024 National Health Interview Survey.medRxiv : the preprint server for health sciences · 2026Article
- Factors Modulating the Effects of Juvenile Social Isolation on Adult Social Behavior in Rodents.Developmental psychobiology · 2026Review
- A narrative review on oxytocin at the intersection of sleep, stress, and social behavior.Frontiers in neuroscience · 2026Review
- Impact of early social isolation on social circuits and behavior: relevance to schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The role of neuroactive steroids in psychiatric and neurological disorders: Neurobiology and therapeutic perspectives.Neuroscience and biobehavioral reviews · 2025Review
- Adolescent social isolation associated changes in ethanol-induced dopamine regulation in the ventral pallidum.Addiction neuroscience · 2025Article
- Early life adversity and adult attention-deficit/hyperactivity disorder (ADHD): Pathways to persistence and adult susceptibility.Neuroscience and biobehavioral reviews · 2025Review
- Adolescent isolation disrupts medial amygdala and ventral tegmental area maturation and sex-specifically dysregulates transcriptional responses to cocaine and stress.Neuropharmacology · 2025Article
- Amygdala AVPR1A mediates susceptibility to chronic social isolation in female mice.Nature communications · 2025Article
- The function of the ZFP189 transcription factor in the nucleus accumbens facilitates cocaine-specific transcriptional and behavioral adaptations.Molecular psychiatry · 2025Article
- Effects of Adolescent Social Isolation on PFC's β-Catenin Levels and Anxiety-Like Behaviors in Male and Female Rats: Study of the Role of Dopaminergic D2 Receptors.Journal of molecular neuroscience : MN · 2025Article
- Juvenile social isolation in Sprague Dawley rats does not have a lasting impact on social behavior in adulthood.Scientific reports · 2025Article
- Early life stress paired with adolescent alcohol consumption reduces two-bottle choice alcohol consumption in mice.Alcohol, clinical & experimental research · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Adolescence is a developmental period associated with vast neural and behavioral changes which are accompanied by altered sensitivity to stimuli, both stressful and rewarding. Perturbations, especially stressful stimuli, during this period have been shown to alter behavior in adulthood. Social isolation rearing is one such perturbation. This review highlights the long-term behavioral consequences of adolescent social isolation rearing in rodents with a specific focus on anxiety- and addiction-related behaviors. Sex-specific effects are discussed where data are available. We then consider changes in monoaminergic neurotransmission as one possible mechanism for the behavioral effects described. This research on both normative and perturbed adolescent development is crucial to understanding and treating the increased vulnerability to psychiatric disorders seen in humans during this life stage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.