Evidence map›Paper›PMID 31031581›Full record

ArticleFrontiers in neuroscience2019

Cognitive Training and Transcranial Direct Current Stimulation in Mild Cognitive Impairment: A Randomized Pilot Trial.

Namrata Das, Jeffrey S Spence, Sina Aslan, Sven Vanneste, Raksha Mudar, Audette Rackley, Mary Quiceno, Sandra Bond Chapman

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04869111 narecruitingnot on this mapstarted 2020, after this paper: background citation

The BrainHealth Project, a Longitudinal Study in Generally Healthy Adults

TypeinterventionalSponsorThe University of Texas at DallasRan2020 to 2038Enrolled100,000ConditionsHealthyArmsBrainHealth App-Based Program
NCT05444231 nacompletednot on this mapstarted 2023, after this paper: background citation

Breaking Through the Brain Fog: An Online RCT for Breast Cancer Survivors

TypeinterventionalSponsorThe University of Texas at DallasRan2023 to 2025Enrolled193ConditionsBreast Cancer FemaleArmsBrain Training A, Brain Training B, Brain Training C
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Namrata DasCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX, United States.
Jeffrey S SpenceCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX, United States.
Sina AslanCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX, United States.
Sven VannesteCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX, United States.
Raksha MudarDepartment of Speech and Hearing Science, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Audette RackleyCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX, United States.
Mary QuicenoUniversity of North Texas Health Science Center and Department of Internal Medicine and Geriatrics and TCU/UNTHSC, School of Medicine, Department of Medical Education, Fort Worth, TX, United States.
Sandra Bond ChapmanCenter for BrainHealth, The University of Texas at Dallas, Dallas, TX, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS), a non-invasive stimulation, represents a potential intervention to enhance cognition across clinical populations including Alzheimer's disease and mild cognitive impairment (MCI). This randomized clinical trial in MCI investigated the effects of anodal tDCS (a-tDCS) delivered to left inferior frontal gyrus (IFG) combined with gist-reasoning training (SMART) versus sham tDCS (s-tDCS) plus SMART on measures of cognitive and neural changes in resting cerebral blood flow (rCBF). We were also interested in SMART effects on cognitive performance regardless of the tDCS group.

methodsTwenty-two MCI participants, who completed the baseline cognitive assessment (T1), were randomized into one of two groups: a-tDCS + SMART and s-tDCS + SMART. Of which, 20 participants completed resting pCASL MRI scan to measure rCBF. Eight SMART sessions were administered over 4 weeks with a-tDCS or s-tDCS stimulation for 20 min before each session. Participants were assessed immediately (T2) and 3-months after training (T3).

resultsSignificant group × time interactions showed cognitive gains at T2 in executive function (EF) measure of inhibition [DKEFS- Color word (

conclusionOne intriguing finding is a-tDCS to left IFG plus SMART increased blood flow to right MFC, however, the stimulation seemingly blocked cognitive benefits of SMART on EF (inhibition and innovation) and episodic memory compared to s-tDCS + SMART group. Although the sample size is small, this paper contributes to growing evidence that cognitive training provides a way to significantly enhance cognitive performance in adults showing memory loss, where the role of a-tDCS in augmenting these effects need further study.

Indexed as

Alzheimer’s diseasebrain modulationcerebral blood flowcognitive trainingfMRImild cognitive impairmentstrategic memory advanced reasoning trainingtranscranial direct current stimulation

Identifiers

PMID31031581
PMCPMC6473050

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.