ArticleJournal of Raman spectroscopy : JRS2018
Biochemical fingerprint of colorectal cancer cell lines using label-free live single-cell Raman spectroscopy.
Article in Journal of Raman spectroscopy : JRS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Automated smartphone based cell analysis platform.Npj imaging · 2025Article
- Raman micro-spectroscopy reveals the metabolic alterations in primary prostate tumor tissues of patients with metastases.Journal of translational medicine · 2025Article
- Raman spectroscopic deep learning with signal aggregated representations for enhanced cell phenotype and signature identification.PNAS nexus · 2024Article
- Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Understanding radiation response and cell cycle variation in brain tumour cells using Raman spectroscopy.The Analyst · 2023Article
- Gold Nanoparticles Synthesized with Common Mullein (Pharmaceutics · 2022Article
- A Deep Learning Approach for Detecting Colorectal Cancer via Raman Spectra.BME frontiers · 2022Article
- MEX3A knockdown inhibits the tumorigenesis of colorectal cancer via modulating CDK2 expression.Experimental and therapeutic medicine · 2021Article
- Article
- Recent Advances on the Model, Measurement Technique, and Application of Single Cell Mechanics.International journal of molecular sciences · 2020Review
- Similarities in the General Chemical Composition of Colon Cancer Cells and Their Microvesicles Investigated by Spectroscopic Methods-Potential Clinical Relevance.International journal of molecular sciences · 2020Article
- Selective Detection of Nano-Sized Diagnostic Markers Using Au-ZnO Nanorod-Based Surface-Enhanced Raman Spectroscopy (SERS) in Ureteral Obstruction Models.International journal of nanomedicine · 2020Article
- Raman spectrum spectral imaging revealing the molecular mechanism of Berberine-induced Jurkat cell apoptosis and the receptor-mediated Berberine delivery system.Biomedical optics express · 2019Article
- Cells Under Stress: An Inertial-Shear Microfluidic Determination of Cell Behavior.Biophysical journal · 2019Article
- Tandem fluorescence and Raman (fluoRaman) characterisation of a novel photosensitiser in colorectal cancer cell line SW480.The Analyst · 2018Article
- Biochemical fingerprint of colorectal cancer cell lines using label-free live single-cell Raman spectroscopy.Journal of Raman spectroscopy : JRS · 2018Article
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7 authors.
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Abstract
Label-free live single-cell Raman spectroscopy was used to obtain a chemical fingerprint of colorectal cancer cells including the classification of the SW480 and SW620 cell line model system, derived from primary and secondary tumour cells from the same patient. High-quality Raman spectra were acquired from hundreds of live cells, showing high reproducibility between experiments. Principal component analysis with linear discriminant analysis yielded the best cell classification, with an accuracy of 98.7 ± 0.3% (standard error) when compared with discrimination trees or support vector machines. SW480 showed higher content of the disordered secondary protein structure Amide III band, whereas SW620 showed larger α-helix and β-sheet band content. The SW620 cell line also displayed higher nucleic acid, phosphates, saccharide, and CH
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