ArticleTrends in analytical chemistry : TRAC2018
Challenges in Mass Spectrometry-based Lipidomics of Neutral Lipids.
Article in Trends in analytical chemistry : TRAC, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Lipidomic profiling of influenza A virus production in MDCK cells towards targeted clone selection.Scientific reports · 2026Article
- Polymorphic Structures and Transitions of Triglycerides and Complex Fats: A Guide to X-Ray Scattering Approaches.Comprehensive reviews in food science and food safety · 2025Review
- Comprehensive lipidome of human plasma using minimal sample manipulation by liquid chromatography coupled with mass spectrometry.Rapid communications in mass spectrometry : RCM · 2025Article
- Novel Charge-Switch Derivatization Method Using 3-(Chlorosulfonyl)benzoic Acid for Sensitive RP-UHPLC/MS/MS Analysis of Acylglycerols, Sterols, and Prenols.Analytical chemistry · 2025Article
- Exploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids.International journal of pharmaceutics: X · 2024Review
- Targeted Mass Spectrometry Reveals Interferon-Dependent Eicosanoid and Fatty Acid Alterations in Chronic Myeloid Leukaemia.International journal of molecular sciences · 2023Article
- Dynamic lipidome alterations associated with human health, disease and ageing.Nature metabolism · 2023Article
- Improving Quantitative Accuracy in Nontargeted Lipidomics by Evaluating Adduct Formation.Analytical chemistry · 2023Article
- Associations of the Lipidome with Ageing, Cognitive Decline and Exercise Behaviours.Metabolites · 2022Review
- Mass Spectrometry-Based Analysis of Lipid Involvement in Alzheimer's Disease Pathology-A Review.Metabolites · 2022Review
- Advances in Analyzing the Breast Cancer Lipidome and Its Relevance to Disease Progression and Treatment.Journal of mammary gland biology and neoplasia · 2021Review
- In-depth triacylglycerol profiling using MSAnalytica chimica acta · 2021Article
- Article
- Structural elucidation of triacylglycerol using online acetone Paternò-Büchi reaction coupled with reversed-phase liquid chromatography mass spectrometry.The Analyst · 2020Article
- Article
- Serum lipidome screening in patients with stage I non-small cell lung cancer.Clinical and experimental medicine · 2019Article
- Advances in Research on Diabetes by Human Nutriomics.International journal of molecular sciences · 2019Review
- Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation.Journal of the American Chemical Society · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Mass spectrometry has played a critical role in the identification and quantitation of neutral lipids such as cholesteryl esters and triacylglycerols present in biological extracts. Various strategies have emerged in order to carry out such lipidomics studies since a large number of neutral lipid molecular species exist in tissues. These include both shotgun approaches as well as those engaging liquid chromatographic separation of species prior to mass spectrometric analysis. Nonetheless challenges remain at every level of the lipidomics experiment, including extraction of lipids, identification of specific species, and quantitation of the vast array of lipids present in the sample extract. Unambiguous identification of molecular species present (qualitative analysis) as well as precise quantitation remains as significant challenges. The relative quantitation enables quite accurate assessment of fold changes of complex lipid species without exact quantitation. The availability of reference standard material as well as relevant internal standards continue to be limited.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.