ArticleCell chemical biology2019
Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.
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Article in Cell chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Phosphoinositides and inositol phosphates as molecular glues.FEBS letters · 2026Review
- A non-classical necroptosis pathway mediated by caspases.Cell communication and signaling : CCS · 2026Article
- Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis.Cell reports · 2026Article
- Mixed Lineage Kinase Domain-Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Article
- Necroptosis-based glioblastoma prognostic subtypes: implications for TME remodeling and therapy response.Annals of medicine · 2024Article
- Cell death: Revisiting the roads to ruin.Developmental cell · 2024Review
- Osteogenesis imperfecta type 10 and the cellular scaffolds underlying common immunological diseases.Genes and immunity · 2024Review
- Parkinson's disease models and death signaling: what do we know until now?Frontiers in neuroanatomy · 2024Review
- Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.Nature communications · 2023Article
- From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors.Journal of medicinal chemistry · 2023Review
- Exploring a diverse world of effector domains and amyloid signaling motifs in fungal NLR proteins.PLoS computational biology · 2022Article
- Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL.Cell death and differentiation · 2022Article
- Necroptosis at a glance.Journal of cell science · 2022Article
- The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.Cell death & disease · 2022Article
- Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes.Cell death and differentiation · 2022Article
- A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma.Frontiers in immunology · 2022Review
- Positive Charges in the Brace Region Facilitate the Membrane Disruption of MLKL-NTR in Necroptosis.Molecules (Basel, Switzerland) · 2021Article
- Inositol Polyphosphate Multikinase Signaling: Multifaceted Functions in Health and Disease.Molecules and cells · 2021Review
- Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Dan E McNamaraDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Cole M DoveyDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Andrew T HaleDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Giovanni QuaratoDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Christy R GraceDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Cristina D GuibaoDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jonathan DiepDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Amanda NourseMolecular Interaction Analysis Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Casey R CaiDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hong WuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ravi C KalathurDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Douglas R GreenDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
John D YorkDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Jan E CaretteDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: carette@stanford.edu.
Tudor MoldoveanuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: tudor.moldoveanu@stjude.org.
St. Jude Children's Research Hospital · USStanford University · USVanderbilt University · USStanford Medicine · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MMOLECULAR BASIS OF HOST-PARASITE INTERACTIONT32AI007328 · NIAID · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 1987 to 2026
$11.9MMECHANISMS OF REGULATED CELL DEATHR35CA231620 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Douglas R. Green · 2018 to 2026
$9.2MPROFESSIONAL ONCOLOGY EDUCATION PROGRAMR25CA023944 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE A. GRONEMEYER · 1986 to 2026
$8.3MSurvival Function of the Fadd-Caspase-8-Flip ComplexR01AI044828 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GREEN, DOUGLAS R. · 1999 to 2016
$6.3MSurvival Function of the Fadd-Caspase-8-Flip Complex - MERIT ExtensionR37AI044828 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Douglas R. Green · 2017 to 2026
$4.5MTo the edge of necroptosis and backR01CA169291 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GREEN, DOUGLAS R. · 2012 to 2018
$2.6MGenetic screens to find critical host factors for SARS-CoV-2 infectionR01AI140186 · NIAID · STANFORD UNIVERSITY · PI CARETTE, JAN E · 2019 to 2023
$2.3MGenetic approaches to discover host factors critical to dengue virus infectionDP2AI104557 · NIAID · STANFORD UNIVERSITY · PI CARETTE, JAN E · 2012 to 2012
$2.3MInositol hexakisphosphate regulation of N-terminal acetyltransferasesR01GM124404 · NIGMS · VANDERBILT UNIVERSITY · PI YORK, JOHN D. · 2017 to 2020
$1.6MAlterations in the sulfur assimilation pathway mediates iron metabolismF30HL143826 · NHLBI · VANDERBILT UNIVERSITY · PI HALE, ANDREW T · 2018 to 2020
$99kNCI NIH HHS P30 CA021765NCI NIH HHS R01 CA169291NCI NIH HHS R25 CA023944NCI NIH HHS R35 CA231620NHLBI NIH HHS F30 HL143826NIAID NIH HHS DP2 AI104557NIAID NIH HHS R01 AI044828NIAID NIH HHS R01 AI140186NIAID NIH HHS R37 AI044828NIAID NIH HHS T32 AI007328NIGMS NIH HHS R01 GM124404
Abstract
Necroptosis is an inflammatory form of programmed cell death executed through plasma membrane rupture by the pseudokinase mixed lineage kinase domain-like (MLKL). We previously showed that MLKL activation requires metabolites of the inositol phosphate (IP) pathway. Here we reveal that I(1,3,4,6)P
Indexed as
AnimalsCell SurvivalHT29 CellsHumansInositol PhosphatesProtein KinasesSf9 CellsSpodopteraInositol PhosphatesMLKL protein, humanProtein Kinasescell deathCRISPR Cas9 gene editinginositol phosphateinositol phosphate kinasemembrane permeabilizationmetaboliteMLKLnecroptosisNMR structure determinationplasma membrane rupture
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