Evidence map›Paper›PMID 31031087›Full record

Observational studyAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2019

Association Between Hypertension and Kidney Function Decline: The Atherosclerosis Risk in Communities (ARIC) Study.

Zhi Yu, Casey M Rebholz, Eugenia Wong, Yuan Chen, Kunihiro Matsushita, Josef Coresh, Morgan E Grams

Abstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. PREDICT Tool for Pregnancy-Associated CKD Progression.Kidney international reports · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Impact of Metabolic Syndrome Traits on Kidney Disease Risk in Individuals with MASLD: A UK Biobank Study.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. The association between the estimated glomerular filtration rate and cognitive impairment: the Suita Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Zhi YuDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD.
Casey M RebholzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD.
Eugenia WongDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD.
Yuan ChenDepartment of Biostatistics, Columbia University Mailman School of Public Health, New York, NY.
Kunihiro MatsushitaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD.
Morgan E GramsWelch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD; Division of Nephrology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address: mgrams2@jhmi.edu.

Funding

Metabolomics for Identifying Biomarkers of Dietary Intake & Kidney Disease ProgressionK01DK107782 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI REBHOLZ, CASEY MARIE · 2016 to 2020
$778k
Dietary Biomarkers and Cardioprotective Mechanisms of the DASH-Sodium Diet.R21HL143089 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI REBHOLZ, CASEY MARIE · 2018 to 2019
$258k
NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R21 HL143089NIDDK NIH HHS K01 DK107782
6 · The paper itself

Abstract

RATIONALE &

objectiveThe relationship between hypertension, antihypertension medication use, and change in glomerular filtration rate (GFR) over time among individuals with preserved GFR requires investigation. STUDY

designObservational study. SETTING &

participants14,854 participants from the Atherosclerosis Risk in Communities (ARIC) Study. PREDICTORS: Baseline hypertension status (1987-1989) was categorized according to the 2017 American College of Cardiology/American Heart Association Clinical Practice Guideline as normal blood pressure, elevated blood pressure, stage 1 hypertension, stage 2 hypertension without medication, or stage 2 hypertension with medication. OUTCOMES: Slope of estimated GFR (eGFR) at 5 study visits over 30 years. ANALYTICAL APPROACH: Mixed models with random intercepts and random slopes were fit to evaluate the association between baseline hypertension status and slope of eGFR.

resultsAt baseline, 13.2%, 7.3%, and 19.4% of whites and 15.8%, 14.9%, and 39.9% of African Americans had stage 1 hypertension, stage 2 hypertension without medication, and stage 2 hypertension with medication. Compared with those with normal blood pressure, the annual eGFR decline was greater in people with higher blood pressure (whites: elevated blood pressure, -0.11mL/min/1.73m LIMITATIONS: Slope estimated using a maximum of 5 eGFR assessments; differential loss to follow-up.

conclusionsCompared to normotension, baseline hypertension status was associated with faster kidney function decline over 30-year follow-up in a general population cohort. This difference was attenuated among people using antihypertensive medications.

Indexed as

Antihypertensive AgentsAtherosclerosisBlack or African AmericanFemaleFollow-Up StudiesGlomerular Filtration RateHumansHypertensionKidneyMaleMiddle AgedProspective StudiesTime FactorsWhite PeopleAntihypertensive AgentsAfrican Americansblood pressurechronic kidney disease (CKD)CKD riskdisease projectionestimated glomerular filtration rate (eGFR)Hypertensionkidney functionraceracial differencestrajectory

Identifiers

PMID31031087
PMCPMC6760841

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.