Evidence map›Paper›PMID 31031021›Full record

ReviewTrends in cognitive sciences2019

Testing Models of Human Declarative Memory at the Single-Neuron Level.

Ueli Rutishauser

Abstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  5. Article
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  9. Article
  10. The Architecture of Human Memory: Insights from Human Single-Neuron Recordings.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Ueli RutishauserDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Electronic address: ueli.rutishauser@cshs.org.

Funding

The Neurobiology of Social Decision-Making: Social Inference and ContextP50MH094258 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ADOLPHS, RALPH · 2012 to 2021
$18.6M
Neuronal mechanisms of human episodic memoryU01NS103792 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI MAMELAK, ADAM NATHANIEL, RUTISHAUSER, UELI · 2017 to 2019
$3.5M
Single-neuron mechanisms of executive control of long-term memory processes in humansR01MH110831 · NIMH · CEDARS-SINAI MEDICAL CENTER · PI RUTISHAUSER, UELI · 2016 to 2020
$2.2M
NIMH NIH HHS P50 MH094258NIMH NIH HHS R01 MH110831NINDS NIH HHS U01 NS103792
6 · The paper itself

Abstract

Deciphering the mechanisms of declarative memory is a major goal of neuroscience. While much theoretical progress has been made, it has proven difficult to experimentally verify key predictions of some foundational models of memory. Recently, single-neuron recordings in human patients have started to provide direct experimental verification of some theories, including mnemonic evidence accumulation, balance-of-evidence for confidence judgments, sparse coding, contextual reinstatement, and the ventral tegmental area (VTA)-hippocampus loop model. Here, we summarize the cell types that have been described in the medial temporal lobe and posterior parietal cortex, discuss their properties, and reflect on how these findings inform theoretical work. This body of work exemplifies the scientific power of a synergistic combination of modeling and human single-neuron recordings to advance cognitive neuroscience.

Indexed as

Models, NeurologicalCognitionDopaminergic NeuronsHippocampusHumansMemoryNeural PathwaysNeuronsSubstantia NigraTemporal Lobedeclarative memorydopaminehippocampusmedial temporal lobememory retrievalsingle-neuron level

Identifiers

PMID31031021
PMCPMC6637968

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.