Evidence map›Paper›PMID 31031006›Full record

ArticleCell2019

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue.

Jun Nagai, Abha K Rajbhandari, Mohitkumar R Gangwani, Ayaka Hachisuka, Giovanni Coppola, Sotiris C Masmanidis, Michael S Fanselow, Baljit S Khakh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers.

0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

194 citing papers in PubMed, 339 citations in OpenAlex.

  1. Article
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  3. Striatal cholinergic and dopaminergic driven astrocyte CabioRxiv : the preprint server for biology · 2026
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134 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jun NagaiDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA.
Abha K RajbhandariDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA.
Mohitkumar R GangwaniDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA.
Ayaka HachisukaDepartment of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA.
Giovanni CoppolaDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA.
Sotiris C MasmanidisDepartment of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA.
Michael S FanselowDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA.
Baljit S KhakhDepartment of Physiology, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA. Electronic address: bkhakh@mednet.ucla.edu.
University of California, Los Angeles · USNeurobehavioral Systems · US

Funding

Fundamental astrocyte biology in intact neural circuitsR35NS111583 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Baljit Khakh · 2019 to 2026
$7.9M
Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI, FREIMER, NELSON B. · 2009 to 2018
$7.4M
Contextual Fear Differentiation, Sex Differences and AcetylcholineR01MH062122 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FANSELOW, MICHAEL S · 2001 to 2021
$7.3M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
Functions of astrocyte calcium signaling in the striatumR01NS060677 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHAKH, BALJIT · 2008 to 2018
$4.3M
Astrocyte branchlet dysfunction as an early step in brain disordersDP1MH104069 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHAKH, BALJIT · 2013 to 2017
$3.9M
Regulation of nucleus accumbens reward processing by diverse input signalsR01DA042739 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MASMANIDIS, SOTIRIS · 2017 to 2021
$1.7M
CRCNS: Network mechanisms of the learning and encoding of timed motor responsesR01NS100050 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUONOMANO, DEAN V, MASMANIDIS, SOTIRIS · 2016 to 2020
$1.5M
NICHD NIH HHS U54 HD087101NIDA NIH HHS R01 DA042739NIMH NIH HHS DP1 MH104069NIMH NIH HHS R01 MH062122NINDS NIH HHS P30 NS062691NINDS NIH HHS R01 NS060677NINDS NIH HHS R01 NS100050NINDS NIH HHS R35 NS111583
6 · The paper itself

Abstract

Hyperactivity and disturbances of attention are common behavioral disorders whose underlying cellular and neural circuit causes are not understood. We report the discovery that striatal astrocytes drive such phenotypes through a hitherto unknown synaptic mechanism. We found that striatal medium spiny neurons (MSNs) triggered astrocyte signaling via γ-aminobutyric acid B (GABA

Indexed as

Behavior, AnimalCell CommunicationSignal TransductionAnimalsAstrocytesAttention Deficit Disorder with HyperactivityFemalegamma-Aminobutyric AcidMaleMiceMice, TransgenicNeuronsReceptors, GABA-BSynapsesThrombospondin 1gamma-Aminobutyric AcidReceptors, GABA-BThbs1 protein, mouseThrombospondin 1astrocyteattention deficitbehaviorcalciumgabapentinhyperactivitymicrocircuitstriatumthrombospondin

Identifiers

PMID31031006
PMCPMC6526045
OpenAlexW2940727119

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.