Evidence map›Paper›PMID 31030596›Full record

ArticleJournal of the American Heart Association2019

Role of Ryanodine Type 2 Receptors in Elementary Ca

Mario Kaßmann, István András Szijártó, Concha F García-Prieto, Gang Fan, Johanna Schleifenbaum, Yoland-Marie Anistan, Christoph Tabeling, Yu Shi, Ferdinand le Noble, Martin Witzenrath and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. The machinery of healthy vasodilatation: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  6. CaInflammation and regeneration · 2025
    Review
  7. Article
  8. Article
  9. Insulin resistance, CaFrontiers in physiology · 2025
    Review
  10. CaInflammation and regeneration · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Mario Kaßmann1 Experimental and Clinical Research Center a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine Charité-Universitätsmedizin Berlin Berlin Germany.
István András Szijártó1 Experimental and Clinical Research Center a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine Charité-Universitätsmedizin Berlin Berlin Germany.
Concha F García-Prieto1 Experimental and Clinical Research Center a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine Charité-Universitätsmedizin Berlin Berlin Germany.
Gang Fan1 Experimental and Clinical Research Center a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine Charité-Universitätsmedizin Berlin Berlin Germany.
Johanna Schleifenbaum1 Experimental and Clinical Research Center a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine Charité-Universitätsmedizin Berlin Berlin Germany.
Yoland-Marie Anistan1 Experimental and Clinical Research Center a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine Charité-Universitätsmedizin Berlin Berlin Germany.
Christoph Tabeling4 Department of Infectious Diseases and Pulmonary Medicine Charité-Universitätsmedizin Berlin Berlin Germany.
Yu Shi5 Medical Clinic for Hematology, Oncology and Tumor Immunology Charité-Universitätsmedizin Berlin Berlin Germany.
Ferdinand le Noble6 Department of Cell and Developmental Biology ITG (Institute of Toxicology and Genetics) Karlsruhe Institute of Technology Karlsruhe Germany.
Martin Witzenrath4 Department of Infectious Diseases and Pulmonary Medicine Charité-Universitätsmedizin Berlin Berlin Germany.
Yu Huang7 Institute of Vascular Medicine and School of Biomedical Sciences Chinese University of Hong Kong China.
Lajos Markó5 Medical Clinic for Hematology, Oncology and Tumor Immunology Charité-Universitätsmedizin Berlin Berlin Germany.
Mark T Nelson8 Department of Pharmacology College of Medicine The University of Vermont Burlington VT.
Maik Gollasch1 Experimental and Clinical Research Center a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine Charité-Universitätsmedizin Berlin Berlin Germany.
Charité - Universitätsmedizin Berlin · DEMax Delbrück Center · DEChinese University of Hong Kong · HKGerman Centre for Cardiovascular Research · DEKarlsruhe Institute of Technology · DEUniversidad San Pablo CEU · ESUniversity of Vermont · US

Funding

Impact of SAH on Parenchymal Arterioles and Neurovascular CouplingP01HL095488 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BONEV, ADRIAN · 2010 to 2014
$11.4M
Ca2+ Sparks and Urinary Bladder Smooth Muscle ExcitabilityR37DK053832 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2008 to 2017
$3.4M
Regulations of Myoendothelial Function By Signaling Microdomains in HypertensionR01HL121706 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2014 to 2017
$1.6M
K+ sensing & electrical signaling by Kir channels in brain vasculatureR01HL131181 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2016 to 2018
$1.4M
NHLBI NIH HHS P01 HL095488NHLBI NIH HHS R01 HL121706NHLBI NIH HHS R01 HL131181NIDDK NIH HHS R37 DK053832
6 · The paper itself

Abstract

Background Hypertension is the major risk factor for cardiovascular disease, the most common cause of death worldwide. Resistance arteries are capable of adapting their diameter independently in response to pressure and flow-associated shear stress. Ryanodine receptors (RyRs) are major Ca

Indexed as

AnimalsAortaArteriesBlood PressureCalcium SignalingHindlimbHypoxiaLarge-Conductance Calcium-Activated Potassium ChannelsLaser-Doppler FlowmetryLungMiceMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleMyographyPatch-Clamp TechniquesLarge-Conductance Calcium-Activated Potassium ChannelsPhosphodiesterase Inhibitorsryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelBKCa channelblood pressureCa2+ sparkshypoxiaisoformspulmonary hypertensionryanodine receptors

Identifiers

PMID31030596
PMCPMC6512102
OpenAlexW2943411338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.