ArticleChild maltreatment2019
Adverse Childhood Experiences and Amygdalar Reduction: High-Resolution Segmentation Reveals Associations With Subnuclei and Psychiatric Outcomes.
Article in Child maltreatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.Molecular psychiatry · 2026Pooled it
- The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis.British journal of anaesthesia · 2023Pooled it
- Subcortical brain structures among maltreated youth with high and low externalizing problems.European child & adolescent psychiatry · 2026Article
- [The Bidirectional relationship between chronic pain and traumatic life events : Mechanisms and therapeutic implications].Schmerz (Berlin, Germany) · 2025Review
- Pathways to adolescent social anxiety: Testing interactions between neural social reward function and perceived social threat in daily life.Development and psychopathology · 2025Article
- The mediating effect of depressive syndrome on the relationship between adverse childhood experiences and chronic kidney diseases among middle-aged and older adults.Frontiers in public health · 2025Article
- Exploring the association between childhood trauma and limbic system subregion volumes in healthy individuals: a neuroimaging study.BMC psychiatry · 2024Article
- Racial Discrimination and Risk for Internalizing and Externalizing Symptoms Among Black Youths.JAMA network open · 2024Article
- In vivo structural analyses of amygdala subregions in relation to stressful life events: A systematic review.Neuroscience applied · 2024Review
- Complex Intersections Between Adverse Childhood Experiences and Negative Life Events Impact the Phenome of Major Depression.Psychology research and behavior management · 2024Article
- Differential alterations of amygdala nuclei volumes in acutely ill patients with anorexia nervosa and their associations with leptin levels.Psychological medicine · 2023Article
- Child maltreatment and youth suicide risk: A developmental conceptual model and implications for suicide prevention.Development and psychopathology · 2023Article
- Distinct Associations of Deprivation and Threat With Alterations in Brain Structure in Early Childhood.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Quantifying numerical and spatial reliability of hippocampal and amygdala subdivisions in FreeSurfer.Brain informatics · 2023Article
- Impact of Socioeconomic Status on Amygdala and Hippocampus Subdivisions in Children and Adolescents.bioRxiv : the preprint server for biology · 2023Article
- The Mediating Role of Brain Structural Imaging Markers in Connecting Adverse Childhood Experiences and Psychological Resilience.Children (Basel, Switzerland) · 2023Article
- Socioeconomic disparities in sleep duration are associated with cortical thickness in children.Brain and behavior · 2023Article
- Effect of transcranial direct current stimulation on postpartum depression: A study protocol for a randomized controlled trial.Frontiers in psychology · 2023Article
- Associations between anxiety, centromedial amygdala volume, and complex verbal fluency in middle-aged to older adults.Journal of clinical and experimental neuropsychology · 2022Article
- Left amygdala structure mediates longitudinal associations between exposure to threat and long-term psychiatric symptomatology in youth.Human brain mapping · 2022Article
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Abstract
The aim of the present study was 2-fold: (1) to utilize improved amygdala segmentation and exploratory factor analysis to characterize the latent volumetric structure among amygdala nuclei and (2) to assess the effect of adverse childhood experiences (ACEs) on amygdalar morphometry and current psychiatric symptoms. To investigate these aims, structural (T1) MRI and self-report data were obtained from 119 emerging adults. Regression analysis showed that higher ACE scores were related to reduced volume of the right, but not the left, amygdalar segments. Further, exploratory factor analysis yielded a two-factor structure, basolateral and central-medial nuclei of the right amygdala. Stractual equation modeling analyses revealed that higher ACE scores were significantly related to a reduced volume of the right basolateral and central-medial segments. Furthermore, reduction in the right basolateral amygdala was associated with increased anxiety, depressive symptoms, and alcohol use. This association supports an indirect effect between early adversity and psychiatric problems via reduced right basolateral amygdalar volume. The high-resolution segmentation results reveal a latent structure among amygdalar nuclei, which is consistent with prior work conducted in nonhuman mammals. These findings extend previous reports linking early adversity, right amygdala volume, and psychopathology.
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