Evidence map›Paper›PMID 31030381›Full record

ReviewJournal of nephrology2019

The role of uric acid in mineral bone disorders in chronic kidney disease.

Baris Afsar, Alan A Sag, Cinar Oztosun, Masanari Kuwabara, Mario Cozzolino, Adrian Covic, Mehmet Kanbay

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 5 countries.

Baris AfsarDivision of Nephrology, Department of Medicine, Suleyman Demirel University School of Medicine, Isparta, Turkey.
Alan A SagDivision of Vascular and Interventional Radiology, Department of Radiology, Duke University Medical Center, Durham, USA.
Cinar OztosunDepartment of Medicine, School of Medicine, Koç University, Istanbul, Turkey.
Masanari KuwabaraDepartment of Cardiology, Toranomon Hospital, Tokyo, Japan.
Mario CozzolinoRenal Division, Department of Health Sciences, University of Milan, 20142, Milan, Italy.
Adrian CovicNephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. PARHON' University Hospital, and 'Grigore T. Popa' University of Medicine, Iasi, Romania.
Mehmet KanbayDivision of Nephrology, Department of Medicine, Koc University School of Medicine, Rumelifeneri Yolu, Sariyer, 34450, Istanbul, Turkey. mkanbay@ku.edu.tr.ORCID http://orcid.org/0000-0002-1297-0675
Koç University · TRDuke Medical Center · USGrigore T. Popa University of Medicine and Pharmacy · ROSüleyman Demirel University · TRToranomon Hospital · JPUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing survival in the chronic kidney disease (CKD) population exposes the bone to the cumulative detrimental sequelae of CKD, now defined physiologically and histopathologically as chronic kidney disease mineral bone disorder (CKD-BMD). This disorder is increasingly recognized as a "nontraditional" driver of morbidity and mortality and presents an opportunity to improve CKD outcomes via research. However, recent advances in the literature on this topic have not yet been collected into a single review. Therefore, this report aims to discuss the disordered renal-bone axis in CKD-BMD, molecular and hormonal drivers, novel treatment strategies, and forthcoming research in a clinician-directed format. A key novel topic will be the unique impact of uric acid on CKD-BMD, which is poised to apply extensive existing research in the uric acid domain to benefit the CKD-BMD population.

Indexed as

Biomedical ResearchChronic Kidney Disease-Mineral and Bone DisorderFibroblast Growth Factor-23ForecastingHumansUric AcidFGF23 protein, humanFibroblast Growth Factor-23Uric AcidFGF-23Mineral bone disorderParathyroid hormoneUric acidVitamin D

Identifiers

PMID31030381
OpenAlexW2940831231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.