ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019
Association among plasma lactate, systemic inflammation, and mild cognitive impairment: a community-based study.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Risk factors for mild cognitive impairment in type 2 diabetes: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Reduced sensorimotor lactate concentration and improved sleep efficiency following resistance training in older adults.GeroScience · 2026Article
- Lactate and cognition: a dual modulator.Frontiers in molecular neuroscience · 2026Review
- Erythrocytes as Active Regulators of Blood Flow: A Brief Overview.Advances in experimental medicine and biology · 2026Review
- Increased Serum Lipopolysaccharide Levels are Related to a Higher Prevalent Risk of Subclinical Hypothyroidism.International journal of endocrinology · 2025Article
- Relationship between preoperative high arterial blood lactate level and delirium after deep brain stimulation surgery in Parkinson's disease.Frontiers in aging · 2025Article
- Exploring mitochondrial blood-based and genetic markers in older adults with mild cognitive impairment and remitted major depressive disorder.Translational psychiatry · 2024Article
- Associations of serum lactate and lactate clearance with delirium in the early stage of ICU: a retrospective cohort study of the MIMIC-IV database.Frontiers in neurology · 2024Article
- Roles of Omega-3 Polyunsaturated Fatty Acids in Managing Cognitive Impairment in Chronic Obstructive Pulmonary Disease: A Review.Nutrients · 2023Review
- Association of Osteoarthritis and Functional Limitations With Cognitive Impairment Among Older Adults in the United States.Journal of aging and health · 2023Article
- Muscle-Brain crosstalk in cognitive impairment.Frontiers in aging neuroscience · 2023Review
- Evidence of Brain Alterations in Noncerebral Falciparum Malaria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders.International journal of molecular sciences · 2022Review
- Poor sleep quality is negatively associated with low cognitive performance in general population independent of self-reported sleep disordered breathing.BMC public health · 2022Article
- Association between 24-h urinary sodium to potassium ratio and mild cognitive impairment in community-based general population.Public health nutrition · 2021Article
- Potential Fluid Biomarkers for the Diagnosis of Mild Cognitive Impairment.International journal of molecular sciences · 2019Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The level of lactate in the blood is associated with obesity, blood pressure, and type 2 diabetes. In addition, lactate is a pro-inflammatory cytokine, which plays an important role in the pathogenesis of cognitive impairment. However, the association between blood lactate, systemic inflammation, and mild cognitive impairment (MCI) has not been investigated. The aim of the study is to explore this association in a Chinese population. This community-based cross-sectional study included 2523 Chinese participants aged 18-88 years. Cognitive function was assessed using the Chinese version of the Mini-Mental State Examination. MCI was defined using education-based cutoffs. The concentration of plasma lactate and serum high-sensitivity C-reactive protein (hs-CRP) was measured using the lactate oxidase method and latex enhanced immunoturbidimetric assay, respectively. Compared with participants without a cognitive impairment, participants with a MCI had an increased concentration of plasma lactate and serum hs-CRP (P < 0.001). As blood lactate increased, the concentration of serum hs-CRP and prevalence of MCI also increased (P < 0.001). Logistic regression analysis showed that plasma lactate (odds ratio (OR) 2.76, 95% confidence interval (CI) 2.21-3.45, P < 0.001) and serum hs-CRP (OR 1.15, 95% CI 1.08-1.24, P < 0.001) were significant risk factors for MCI. The adjusted OR for MCI in participants in the fourth lactate quartile was 3.44 (95% CI 2.02-5.88, P < 0.001) compared with the first quartile. Our results showed that plasma lactate is associated with systemic inflammation and MCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.