Evidence map›Paper›PMID 31030369›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

New evidence-based A1, A2, A3 alarm time zones for transferring thrombolysed patients to hyper-acute stroke units: faster is better.

Thang S Han, Giosue Gulli, Brendan Affley, David Fluck, Christopher H Fry, Christopher Barrett, Puneet Kakar, Sapna Sharma, Pankaj Sharma

Abstract read
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Adverse stroke outcomes amongst UK ethnic minorities: a multi-centre registry-based cohort study of acute stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thang S HanInstitute of Cardiovascular Research, Royal Holloway, University of London, TW20 0EX, Egham, UK. thang.han@rhul.ac.uk.ORCID http://orcid.org/0000-0003-2570-0938
Giosue GulliDepartment of Stroke, Ashford and St Peter's NHS Foundation Trust, KT16 0PZ, Chertsey, UK.
Brendan AffleyDepartment of Stroke, Ashford and St Peter's NHS Foundation Trust, KT16 0PZ, Chertsey, UK.
David FluckDepartment of Cardiology, Ashford and St Peter's NHS Foundation Trust, KT16 0PZ, Chertsey, UK.
Christopher H FrySchool of Physiology, Pharmacology and Neuroscience, University of Bristol, BS8 1QU, Bristol, UK.
Christopher BarrettDepartment of Stroke, NHS Frimley Health Foundation Trust, GU16 7UJ, Frimley, UK.
Puneet KakarDepartment of Stroke, Epsom and St Helier University Hospitals NHS Trust, SM5 1AA, Surrey, UK.
Sapna SharmaInstitute of Cardiovascular Research, Royal Holloway, University of London, TW20 0EX, Egham, UK.
Pankaj SharmaInstitute of Cardiovascular Research, Royal Holloway, University of London, TW20 0EX, Egham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe National Institute of Health and Clinical Excellence and The Royal College of Physicians recommend transferring thrombolysed patients with stroke to a hyperacute stroke unit (HASU) within 4 h from hospital arrival (T

designWe conducted a retrospective analysis of prospectively collected data from the Sentinel Stroke National Audit Programme.

settingFour major UK hyperacute stroke centres between 2014 and 2016.

participantsA total of 183 men (median age = 75 years, IQR = 66-83) and 169 women (median age = 81 years, IQR = 72.5-88) admitted with acute ischaemic stroke.

main outcome measuresWe evaluated T

resultsThere were 51 (14.5%) inpatient deaths. On ROC analysis, the AUC (area under the curve) was 61.1% (52.9-69.4%, p = 0.01) and the cut-off of T

conclusionsWe propose three new alarm time zones (A1, A2 and A3) to improve stroke survival: "A1 Zone" (T

Indexed as

Patient TransferThrombolytic TherapyTime-to-TreatmentAgedAged, 80 and overFemaleFibrinolytic AgentsHospital UnitsHumansMaleMiddle AgedRetrospective StudiesStrokeTime FactorsTissue Plasminogen ActivatorUnited KingdomFibrinolytic AgentsTissue Plasminogen ActivatorEvidence-based medicineIschaemic strokeROC analysisStroke unitsThrombolysistPA

Identifiers

PMID31030369
PMCPMC6647361

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.