ArticleAbdominal radiology (New York)2019
Extracapsular extension on MRI indicates a more aggressive cell cycle progression genotype of prostate cancer.
Article in Abdominal radiology (New York), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Review
- A New Radiotranscriptomic Approach to Analyze Combined Sets of T3b Stage-Specific Genes and Radiomic Features in Prostate Cancer.Cancer reports (Hoboken, N.J.) · 2025Article
- Comparing Multigene Molecular Testing Results of MRI-Target Versus Systematic Prostate Needle Biopsies of Candidates for and Under Active Surveillance.Journal of personalized medicine · 2025Article
- Evaluation of 3D ARFI imaging of prostate cancer: diagnostic reliability and concordance with MpMRI.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Integration of Genomic Tests in Prostate Cancer Care: Implications for Clinical Practice and Patient Outcomes.Current issues in molecular biology · 2024Review
- The role of MRI in prostate cancer: current and future directions.Magma (New York, N.Y.) · 2022Review
- A review on the role of tissue-based molecular biomarkers for active surveillance.World journal of urology · 2022Review
- Prostate Cancer Radiogenomics-From Imaging to Molecular Characterization.International journal of molecular sciences · 2021Review
- Radiomics and Radiogenomics in Evaluation of Colorectal Cancer Liver Metastasis.Frontiers in oncology · 2021Review
- Background, applications and challenges of radiogenomics in genitourinary tumor.American journal of cancer research · 2021Review
- Genetic Landscape of Prostate Cancer Conspicuity on Multiparametric Magnetic Resonance Imaging: A Systematic Review and Bioinformatic Analysis.European urology open science · 2020Review
- Radiogenomics influence on the future of prostate cancer risk stratification.Therapeutic advances in urologyReview
- Prostate cancer biomarkers and multiparametric MRI: is there a role for both in prostate cancer management?Therapeutic advances in urologyReview
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Authors and funding
9 authors.
Funding
Abstract
purposeTo explore associations between magnetic resonance imaging (MRI) features of prostate cancer and expression levels of cell cycle genes, as assessed by the Prolaris MATERIALS AND
methodsRetrospective analysis of 118 PCa patients with genetic testing of biopsy specimen and prostate MRI from 08/2013 to 11/2015. Associations between the cell cycle risk (CCR) score and MRI features [i.e., PI-RADSv2 score, extracapsular extension (ECE), quantitative metrics] were analyzed with Fisher's exact test, nonparametric tests, and Spearman's correlation coefficient. In 41 patients (34.7%), test results were compared to unfavorable features on prostatectomy specimen (i.e., Gleason group ≥ 3, ECE, lymph node metastases).
resultsFifty-four (45.8%), 60 (50.8%), and 4 (3.4%) patients had low-, intermediate-, and high-risk cancers according to American Urological Association scoring system. Patients with ECE on MRI had significantly higher mean CCR scores (reader 1: 3.9 vs. 3.2, p = 0.015; reader 2: 3.6 vs. 3.2, p = 0.045). PI-RADSv2 scores and quantitative MRI features were not associated with CCR scores. In the prostatectomy subset, ECE on MRI (p = < 0.001-0.001) and CCR scores (p = 0.049) were significantly associated with unfavorable histopathologic features.
conclusionThe phenotypic trait of ECE on MRI indicates a more aggressive genotype of prostate cancer.
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