Evidence map›Paper›PMID 31030002›Full record

ReviewBehaviour research and therapy2019

Mechanisms linking childhood adversity with psychopathology: Learning as an intervention target.

Katie A McLaughlin, Stephanie N DeCross, Tanja Jovanovic, Nim Tottenham

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Behaviour research and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katie A McLaughlinDepartment of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA, 02138, USA. Electronic address: kmclaughlin@fas.harvard.edu.
Stephanie N DeCrossDepartment of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA, 02138, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, 3901 Chrysler Dr, Detroit, MI, 48201, USA; Department of Psychiatry and Behavioral Sciences, Emory University, 49 Jesse Hill Jr Dr, Atlanta, GA, 30303, USA.
Nim TottenhamDepartment of Psychology, Columbia University, 5501 Amsterdam Avenue, New York, NY, 10027, USA.

Funding

Predicting Heterogeneous Neurodevelopmental Outcomes in School-age Children with Early Caregiving AdversitiesR01MH091864 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MILHAM, MICHAEL PETER, TOTTENHAM, NIM · 2010 to 2022
$5.1M
Child Trauma and the Development of Neural Systems Underlying Emotion RegulationR01MH103291 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2014 to 2018
$3.8M
Deprivation and Threat: Dimensions of Early Experience and Neural DevelopmentR01MH106482 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2016 to 2020
$3.1M
Impact of Trauma Exposure on Critical Periods in Brain Development and Fear Processing in ChildrenR01MH111682 · NIMH · WAYNE STATE UNIVERSITY · PI JOVANOVIC, TANJA · 2016 to 2020
$3.0M
Development, Trauma, and Genotype Effects on Biomarkers of Anxiety in ChildrenR01MH100122 · NIMH · EMORY UNIVERSITY · PI JOVANOVIC, TANJA · 2013 to 2017
$1.9M
NIMH NIH HHS R01 MH091864NIMH NIH HHS R01 MH100122NIMH NIH HHS R01 MH103291NIMH NIH HHS R01 MH106482NIMH NIH HHS R01 MH111682
6 · The paper itself

Abstract

Exposure to childhood adversity is common and a powerful risk factor for many forms of psychopathology. In this opinion piece, we argue for greater translation of knowledge about the developmental processes that are influenced by childhood adversity into targeted interventions to prevent the onset of psychopathology. Existing evidence has consistently identified several neurodevelopmental pathways that serve as mechanisms linking adversity with psychopathology. We highlight three domains in which these mechanisms are well-established and point to clear targets for intervention: 1) threat-related social information processing biases; 2) heightened emotional reactivity and difficulties with emotion regulation; and 3) disruptions in reward processing. In contrast to these established pathways, knowledge of how childhood adversity influences emotional learning mechanisms, including fear and reward learning, is remarkably limited. We see the investigation of these mechanisms as a critical next step for the field that will not only advance understanding of developmental pathways linking childhood adversity with psychopathology, but also provide clear targets for behavioral interventions. Knowledge of the mechanisms linking childhood adversity with psychopathology has advanced rapidly, and the time has come to translate that knowledge into clinical interventions to prevent the onset of mental health problems in children who have experienced adversity.

Indexed as

Adverse Childhood ExperiencesChildFemaleHumansMaleMental DisordersRisk FactorsChildhood adversityDevelopmentEarly interventionEarly-life stressLearningPsychopathology

Identifiers

PMID31030002
PMCPMC6536359

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.