Evidence map›Paper›PMID 31029828›Full record

ArticleActa biomaterialia2019

Improving hard palate wound healing using immune modulatory autotherapies.

Samir A Ballestas, Thomas C Turner, Archana Kamalakar, Yvonne C Stephenson, Nick J Willett, Steven L Goudy, Edward A Botchwey

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Acta biomaterialia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06811974 (Comparison of the Efficiency of Tissue Adhesive), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06811974 nacompletednot on this mapstarted 2022, after this paper: background citation

Comparison of the Efficiency of Tissue Adhesive (Periacryl 90) and Silk Suture in Bilateral Mandibular Impacted Wisdom Dental Surgery

TypeinterventionalSponsorYuzuncu Yil UniversityRan2022 to 2024Enrolled30ConditionsImpacted Mandibular Third Molar ExtractionArmsImpacted lower wisdom tooth extraction
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Biomaterials strategy for promoting palatal wound healing.Frontiers in bioengineering and biotechnology · 2025
    Review
  8. Article
  9. Article
  10. Pharmacological Effects of FTY720 and its Derivatives.Current topics in medicinal chemistry · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. BioinspiredBioactive materials · 2022
    Article
  16. Oral wound healing models and emerging regenerative therapies.Translational research : the journal of laboratory and clinical medicine · 2021
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Samir A BallestasDepartment of Otolaryngology, Emory University School of Medicine, USA. Electronic address: samir.ballestas.naissir@emory.edu.
Thomas C TurnerCoulter Department of Biomedical Engineering, Georgia Tech and Emory, Atlanta, GA, USA; Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: tturner0519@gatech.edu.
Archana KamalakarDepartment of Otolaryngology, Emory University School of Medicine, USA. Electronic address: archana.kamalakar@emory.edu.
Yvonne C StephensonDepartment of Otolaryngology, Emory University School of Medicine, USA. Electronic address: Yvonne.stephenson@emory.edu.
Nick J WillettDepartment of Orthopedics, Emory University School of Medicine, USA; Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: nick.james.willett@emory.edu.
Steven L GoudyDepartment of Otolaryngology, Emory University School of Medicine, USA. Electronic address: steven.goudy@emory.edu.
Edward A BotchweyCoulter Department of Biomedical Engineering, Georgia Tech and Emory, Atlanta, GA, USA; Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: Edward.botchwey@bme.gatech.edu.
Emory University · USGeorgia Institute of Technology · US

Funding

Research Training Program Plan on Cell and Tissue Engineering (CTEng)T32GM008433 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 1991 to 2021
$7.1M
In Vitro Macrophage Response to Therapeutic UltrasoundF31AR052278 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI TURNER, THOMAS T · 2005 to 2006
$61k
NIAMS NIH HHS F31 AR052278NIGMS NIH HHS T32 GM008433
6 · The paper itself

Abstract

Oral cavity wound healing occurs in an environment that sustains ongoing physical trauma and is rich in bacteria. Despite this, injuries to the mucosal surface often heal faster than cutaneous wounds and leave less noticeable scars. Patients undergoing cleft palate repair have a high degree of wound healing complications with up to 60% experiencing oronasal fistula (ONF) formation. In this study, we developed a mouse model of hard palate mucosal injury, to study the endogenous injury response during oral cavity wound healing and ONF formation. Immunophenotyping of the inflammatory infiltrate following hard palate injury showed delayed recruitment of non-classical LY6C

Indexed as

Fingolimod HydrochloridePalate, HardWound HealingAnimalsCytokinesGene Expression RegulationImmunomodulationMacrophagesMiceNanofibersSOXB1 Transcription FactorsCytokinesFingolimod HydrochlorideSox2 protein, mouseSOXB1 Transcription FactorsCleft palateFTY720Oral cavityOronasal fistulaWound healing

Identifiers

PMID31029828
PMCPMC7685787
OpenAlexW2941918058

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.