Evidence map›Paper›PMID 31029683›Full record

ArticleJornal de pediatria

Mannose-binding lectin gene polymorphism and its effect on short term outcomes in preterm infants.

Pelin Dogan, Hilal Ozkan, Nilgun Koksal, Haluk Barbaros Oral, Onur Bagci, Ipek Guney Varal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. [Recent research on gene polymorphisms and genetic susceptibility of neonatal sepsis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pelin DoganUludag University, Faculty of Medicine, Department of Pediatrics, Bursa, Turkey. Electronic address: pelin_akbas@yahoo.com.
Hilal OzkanUludag University, Faculty of Medicine, Department of Pediatrics, Bursa, Turkey.
Nilgun KoksalUludag University, Faculty of Medicine, Department of Pediatrics, Bursa, Turkey.
Haluk Barbaros OralUludag University, Faculty of Medicine, Department of Immunology, Bursa, Turkey.
Onur BagciUludag University, Faculty of Medicine, Department of Pediatrics, Bursa, Turkey.
Ipek Guney VaralUludag University, Faculty of Medicine, Department of Pediatrics, Bursa, Turkey.
Bursa Uludağ Üni̇versi̇tesi̇ · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMannose-binding lectin, which belongs to the collectin family, is an acute-phase reactant that activates the complement system. This study aimed to investigate the effect of MBL2 gene polymorphism on short-term outcomes in preterm infants.

methodInfants of <37 gestational weeks who were admitted to the neonatal intensive care unit during a two-year period were enrolled in this prospective study. The neonates were categorized into two groups according to their MBL2 genotypes. Normal MBL2 genotype was defined as MBL2 wild-type (AA genotype), whereas mutant MBL2 genotype was defined as MBL2 variant-type (AO/OO genotype). The relationship between MBL2 genotype and short-term morbidity and mortality was evaluated.

resultsDuring the two-year study period, 116 preterm infants were enrolled in this study. In MBL2 variant-type, mannose-binding lectin levels were significantly lower and incidences of mannose-binding lectin deficiency (MBL level<700ng/mL) were higher (p<0.001). In this group, the prevalence of respiratory distress syndrome and mortality was significantly higher (p<0.001, p=0.03 respectively). In the MBL2 wild-type group, the prevalence of necrotizing enterocolitis (NEC) was higher (p=0.01). Logistic regression analyses revealed that MBL2 variant-type had a significant effect on respiratory distress syndrome development (odds ratio, 5.1; 95% confidence interval, 2.2-11.9; p<0.001).

conclusionsMBL2 variant-type and mannose-binding lectin deficiency are important risk factors for respiratory distress syndrome development in preterm infants. Additionally, there is an association between MBL2 wild-type and NEC. Further studies on this subject are needed.

Indexed as

Respiratory Distress Syndrome, NewbornGenetic Predisposition to DiseaseGenotypeHumansInfantInfant, NewbornInfant, PrematureMannose-Binding LectinPolymorphism, Single NucleotideProspective StudiesMannose-Binding LectinLectina ligante de manoseMannose-binding lectinPrematuroPretermRespiratory distress syndromeSíndrome do desconforto respiratório

Identifiers

PMID31029683
PMCPMC9432184
OpenAlexW2941484110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.