Evidence map›Paper›PMID 31029155›Full record

ArticleClinical epigenetics2019

Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine.

Maria Herberg, Susann Siebert, Marianne Quaas, Torsten Thalheim, Karen Rother, Michelle Hussong, Janine Altmüller, Christiane Kerner, Joerg Galle, Michal R Schweiger and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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  11. Epigenetics of Cutaneous Sarcoma.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Maria HerbergInterdisciplinary Center for Bioinformatics (IZBI), Leipzig University, Leipzig, Germany.
Susann SiebertLaboratory for Translational Epigenetics and Tumor Genetics, University Hospital Cologne, Cologne, Germany.
Marianne QuaasInterdisciplinary Center for Bioinformatics (IZBI), Leipzig University, Leipzig, Germany.
Torsten ThalheimInterdisciplinary Center for Bioinformatics (IZBI), Leipzig University, Leipzig, Germany.
Karen RotherDepartment of Surgery, Research Laboratories, Leipzig University, Liebigstr. 19, D-04103, Leipzig, Germany.
Michelle HussongLaboratory for Translational Epigenetics and Tumor Genetics, University Hospital Cologne, Cologne, Germany.
Janine AltmüllerCologne Center for Genomics, University of Cologne, Cologne, Germany.
Christiane KernerDepartment of Surgery, Research Laboratories, Leipzig University, Liebigstr. 19, D-04103, Leipzig, Germany.
Joerg GalleInterdisciplinary Center for Bioinformatics (IZBI), Leipzig University, Leipzig, Germany.
Michal R SchweigerLaboratory for Translational Epigenetics and Tumor Genetics, University Hospital Cologne, Cologne, Germany.
Gabriela AustDepartment of Surgery, Research Laboratories, Leipzig University, Liebigstr. 19, D-04103, Leipzig, Germany. gabriela.aust@medizin.uni-leipzig.de.ORCID 0000-0002-4670-4543
Leipzig University · DEUniversity of Cologne · DELeipzig University of Applied Sciences · DEUniversity Hospital Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quantified genome-wide histone H3 methylation profiles in macroscopic normal intestinal tissue of young radiated and untreated MMR-deficient VCMsh2

resultsHistone H3 methylation increases in Msh2

conclusionsMMR deficiency results in genome-wide changes in histone H3 methylation profiles preceding tumor development. Similar changes constitute a persistent epigenetic signature of radiation-induced DNA damage.

Indexed as

AgedAnimalsCase-Control StudiesChromatin Immunoprecipitation SequencingDisease Models, AnimalEpigenesis, GeneticFemaleGene Regulatory NetworksHistonesHumansIntestinal NeoplasmsIntestinesMaleMiceMutS Homolog 2 ProteinWhole Genome SequencingHistonesMSH2 protein, humanMutS Homolog 2 ProteinHistone H3 methylationIntestineMismatch repair deficiencyMsh2Radiation

Identifiers

PMID31029155
PMCPMC6486978
OpenAlexW2947424290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.