Observational studyPediatric research2019
Changes in hemodynamics, cerebral oxygenation and cerebrovascular reactivity during the early transitional circulation in preterm infants.
Observational study in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Cerebrovascular autoregulation and preterm brain injury: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- Cerebral Oximetry in Extremely Preterm Infants: 2-Year Follow-Up of the SafeBoosC-III Randomized Clinical Trial.JAMA pediatrics · 2026Trial
- Trial
- Hemodynamic effect of delayed cord clamping versus early cord clamping in preterm twins using echocardiography: a prospective observational study.Pediatric research · 2026Article
- Measuring cerebral hemodynamics and oxygen metabolism indices using NIR-TRS in premature infants from birth to term-equivalent age.Scientific reports · 2025Article
- Neonatal Shock: Current Dilemmas and Future Research Avenues.Children (Basel, Switzerland) · 2025Review
- Higher in-hospital proportion of breast milk intake improves brain functional connectivity and neurological assessment in preterm infants.Frontiers in pediatrics · 2025Article
- Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Cardiovascular and cerebrovascular effects of caffeine maintenance in preterm infants during the transitional period.Pediatric research · 2024Observational
- Near-infrared spectroscopy monitoring of neonatal cerebrovascular reactivity: where are we now?Pediatric research · 2024Review
- The Role of Oxidative Stress in the Progression of Secondary Brain Injury Following Germinal Matrix Hemorrhage.Translational stroke research · 2024Review
- Insights into Neonatal Cerebral Autoregulation by Blood Pressure Monitoring and Cerebral Tissue Oxygenation: A Qualitative Systematic Review.Children (Basel, Switzerland) · 2023Review
- Neuromonitoring in neonatal critical care part II: extremely premature infants and critically ill neonates.Pediatric research · 2023Review
- Cerebral monitoring of very preterm infants with anterior cerebral artery resistive index and early NIRS.Turkish journal of medical sciences · 2023Article
- Relationship between cerebral oxygenation, cardiac output, and blood pressure during transitional period in extremely low gestational age neonates.Frontiers in pediatrics · 2023Article
- [Influence of hypotension on the short-term prognosis of preterm infants with a gestational age of <32 weeks].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Association of early cerebral oxygen saturation and brain injury in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Clinical determinants of cerebrovascular reactivity in very preterm infants during the transitional period.Pediatric research · 2022Observational
- Association Analysis of the Cerebral Fractional Tissue Oxygen Extraction (cFTOE) and the Cerebral Oxygen Saturation (crSaOJournal of clinical medicine · 2022Article
- A neonatal neuroNICU collaborative approach to neuromonitoring of posthemorrhagic ventricular dilation in preterm infants.Pediatric research · 2022Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChanges in systemic and cerebral hemodynamics in preterm infants during early transitional circulation are complex and may differ between infants with or without intraventricular hemorrhage (IVH).
methodIn total, 43 infants born at median (range) 25 + 5 (23 + 3-31) had continuous near-infrared spectroscopy (NIRS) monitoring of tissue oxygenation index (TOI) and cerebrovascular reactivity within the first 48 h of life. Measurements of left and right cardiac outputs (LVO, RVO) and patent ductus arteriosus (PDA) were collected at 6, 12, 24, and 48 h of life.
resultsLVO increased within the first 48 h in the IVH (P = 0.007) and no-IVH (P < 0.001) groups. The pattern of change in LVO and RVO was not different between these two groups. TOI was lower in the IVH (P < 0.001) group. A positive correlation between TOI and LVO (P = 0.003) and a negative correlation between the tissue oxygen reactivity index (TOx) and LVO (P = 0.04) were observed at 24 h of life in the IVH group. PDA diameter was not different between IVH groups at any time interval.
conclusionCerebral oxygenation was lower and cerebrovascular reactivity was passive to systemic blood flow at 24 h in infants who developed an IVH.
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