Evidence map›Paper›PMID 31028838›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2020

Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma.

Weikun Xiao, Shanshan Wang, Rongyu Zhang, Alireza Sohrabi, Qi Yu, Sihan Liu, Arshia Ehsanipour, Jesse Liang, Rebecca D Bierman, David A Nathanson and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 74 citations in OpenAlex.

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  16. Synthetic living materials in cancer biology.Nature reviews bioengineering · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Weikun XiaoDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Shanshan WangDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Rongyu ZhangDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Alireza SohrabiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Qi YuDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Sihan LiuDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Arshia EhsanipourDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Jesse LiangDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Rebecca D BiermanDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
David A NathansonJonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Stephanie K SeidlitsDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, USA; Broad Stem Cell Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA; Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: seidlits@g.ucla.edu.
University of California, Los Angeles · US

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
Training Grant in Genomic Analysis and InterpretationT32HG002536 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie A Arboleda, Harold Pimentel · 2002 to 2026
$8.6M
Mammalian models for integrated metabolic and molecular profiling of malignant gliomaR01CA227089 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRAEBER, THOMAS G, NATHANSON, DAVID A. · 2018 to 2022
$2.7M
Targeting metabolic vulnerabilities in glioblastomaR01CA213133 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NATHANSON, DAVID A. · 2017 to 2021
$2.5M
Engineered microenvironments as biomimetic culture platforms for studying the role of brain extracellular matrix in acquisition of resistance to EGFR inhibition across multiple biological scalesR21NS093199 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NATHANSON, DAVID A., SEIDLITS, STEPHANIE KRISTIN · 2015 to 2016
$424k
NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA213133NCI NIH HHS R01 CA227089NHGRI NIH HHS T32 HG002536NINDS NIH HHS R21 NS093199
6 · The paper itself

Abstract

Originating in the brain, glioblastoma (GBM) is a highly lethal and virtually incurable cancer, in large part because it readily develops resistance to treatments. While numerous studies have investigated mechanisms enabling GBM cells to evade chemotherapy-induced apoptosis, few have addressed how their surrounding extracellular matrix (ECM) acts to promote their survival. Here, we employed a biomaterial-based, 3D culture platform to investigate systematically how interactions between patient-derived GBM cells and the brain ECM promote resistance to alkylating chemotherapies - including temozolomide, which is used routinely in clinical practice. Scaffolds for 3D culture were fabricated from hyaluronic acid (HA) - a major structural and bioactive component of the brain ECM - and functionalized with the RGD (arginine-glycine-aspartic acid) tripeptide to provide sites for integrin engagement. Data demonstrate that cooperative engagement of CD44, through HA, and integrin α

Indexed as

Drug Resistance, NeoplasmBrain NeoplasmsCell Line, TumorCell MovementCell ProliferationExtracellular MatrixGene Expression Regulation, NeoplasticGlioblastomaHumansHyaluronan ReceptorsHyaluronic AcidIntegrin alphaVModels, BiologicalOligopeptidesTemozolomideTissue Scaffoldsarginyl-glycyl-aspartic acidCD44 protein, humanHyaluronan ReceptorsHyaluronic AcidIntegrin alphaVOligopeptidesTemozolomide3D cultureBCL-2 familyCD44ChemotherapyCilengitideDasatinibDrug resistanceExtracellular matrixGlioblastomaHyaluronic acidIntegrinSrc

Identifiers

PMID31028838
PMCPMC6813884
OpenAlexW2942427214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.