Evidence map›Paper›PMID 31028690›Full record

ArticleJournal of neurovirology2019

Progressive multifocal leukoencephalopathy in Zambia is caused by JC virus with prototype regulatory region.

Eugene Mubanga, Atiyah Patel, Omar K Siddiqi, Barbara A Hanson, Xin Dang, Shabir Lakhi, Gina Mulundu, Noemi Bender, Igor J Koralnik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Progressive multifocal leukoencephalopathy and spectrum of predisposing conditions: a 20-year retrospective cohort study in a tertiary center in São Paulo, Brazil.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eugene MubangaDepartment of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
Atiyah PatelDepartment of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
Omar K SiddiqiDepartment of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
Barbara A HansonDepartment of Neurological Sciences, Rush University Medical Center, 1725 W. Harrison Street, Suite 1106, Chicago, IL, 60612, USA.
Xin DangDepartment of Neurological Sciences, Rush University Medical Center, 1725 W. Harrison Street, Suite 1106, Chicago, IL, 60612, USA.ORCID 0000-0003-4570-9016
Shabir LakhiDepartment of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
Gina MulunduDepartment of Pathology and Microbiology, University of Zambia School of Medicine, Lusaka, Zambia.
Noemi BenderInfections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Igor J KoralnikDepartment of Neurological Sciences, Rush University Medical Center, 1725 W. Harrison Street, Suite 1106, Chicago, IL, 60612, USA. igor_koralnik@rush.edu.

Funding

Role of Inflammation in Progressive Multifocal LeukoencephalopathyR01NS047029 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2004 to 2018
$6.4M
CELLULAR IMMUNITY TO JC VIRUS IN AIDS ASSOCIATED PMLR01NS041198 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KORALNIK, IGOR J. · 2001 to 2009
$3.3M
Pathogenesis of a JC Virus Variant in Pyramidal NeuronsR01NS074995 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2012 to 2016
$1.8M
Novel CSF Diagnostics and Genotype Markers of Tuberculous Meningitis in ZambiaK23NS084054 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SIDDIQI, OMAR KHALIK · 2014 to 2018
$910k
NINDS NIH HHS K23 NS084054NINDS NIH HHS R01 NS041198NINDS NIH HHS R01 NS047029NINDS NIH HHS R01 NS074995
6 · The paper itself

Abstract

There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first documented PML cases in Zambia as well as JCV seroprevalence among HIV

Indexed as

AdolescentAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCase-Control StudiesCD4-Positive T-LymphocytesCoinfectionDNA, ViralFemaleGenotypeHenipavirus InfectionsHIVHumansJC VirusLeukoencephalopathy, Progressive MultifocalMaleAnti-HIV AgentsDNA, ViralJCVProgressive multifocal leukoencephalopathyRegulatory regionZambia

Identifiers

PMID31028690
PMCPMC6750969

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.