Evidence map›Paper›PMID 31028592›Full record

ArticleJournal of autism and developmental disorders2019

Mood Disorders in High-Functioning Autism: The Importance of Alexithymia and Emotional Regulation.

Kristen P Morie, Scott Jackson, Zu Wei Zhai, Marc N Potenza, Barbara Dritschel

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Autistic Adult Online Interoception Feasibility Pilot Program.Occupational therapy international · 2026
    Article
  8. Article
  9. Review
  10. Inner experiences, mental health, and well-being in autistic and non-autistic adults.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  11. Article
  12. Examining a model of anxiety in autistic adults.Autism : the international journal of research and practice · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Kristen P MorieDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA. kristen.morie@yale.edu.ORCID http://orcid.org/0000-0001-5220-5604
Scott JacksonDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA. Scott.Jackson@yale.edu.
Zu Wei ZhaiDepartment of Psychology, Middlebury College, Middlebury, VT, 05753, USA.
Marc N PotenzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, 06510, USA.
Barbara DritschelSchool of Psychology & Neuroscience, University of St Andrews, St. Andrews, Fife, KY16 9JP, UK.
Yale University · USMiddlebury College · USUniversity of St Andrews · GB

Funding

TRAINING PROGRAM IN CHILDHOOD NEUROPSYCHIATRIC DISORDERST32MH018268 · NIMH · YALE UNIVERSITY · PI Michael H Bloch, MICHAEL J CROWLEY · 1985 to 2026
$11.0M
Development of Reward Processing in prenatally exposed adolescents and young adultsK01DA042937 · NIDA · YALE UNIVERSITY · PI MORIE, KRISTEN PAULA · 2017 to 2021
$907k
NIDA NIH HHS K01 DA042937NIDA NIH HHS K01DA042937NIH HHS MH018268-31NIH HHS MH018268-33NIMH NIH HHS T32 MH018268
6 · The paper itself

Abstract

Individuals with autism spectrum disorder (ASD) often have co-morbid anxiety and depression. Alexithymia and emotion regulation difficulties are commonly seen in individuals with ASD and in mood disorders. We hypothesized that alexithymia and emotional regulation would mediate the relationship between autistic features and anxiety/depression symptom severity. We collected data about emotional regulation, alexithymia, autistic symptoms and depression/anxiety in a sample of 64 young adults with ASD. We constructed two serial multiple mediator models, using autistic features as the independent variable and anxiety/depression symptoms as outcome variables. The serial relationship between alexithymia and emotional regulation mediated associations between autistic features and depression and anxiety, separately. The findings suggest that targeting alexithymia may benefit therapies designed to alleviate mood disorders in ASD.

Indexed as

EmotionsAdolescentAdultAffective SymptomsAgedAnxietyAnxiety DisordersAsperger SyndromeAutism Spectrum DisorderComorbidityDepressionFemaleHumansMaleMiddle AgedMood DisordersAlexithymiaASDAutismEmotional regulationMood disorders

Identifiers

PMID31028592
PMCPMC7375152
OpenAlexW2940821081

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.