Evidence map›Paper›PMID 31028561›Full record

ArticleInternational urology and nephrology2019

Desmopressin for the prevention of bleeding in percutaneous kidney biopsy: efficacy and hyponatremia.

Cynthia C Lim, Benson Siow, Jason C J Choo, Mayank Chawla, Yok Mooi Chin, Terence Kee, Puay Hoon Lee, Marjorie Foo, Chieh Suai Tan

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In one paragraph

Article in International urology and nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
  5. Review
  6. Article
  7. Article
  8. Image-guided renal parenchymal biopsies- how we do it.Abdominal radiology (New York) · 2025
    Review
  9. When our intuition lets us down-something believed to be beneficial may actually be harmful.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
    Article
  10. Article
  11. The Role of Desmopressin in Kidney Biopsies: A Narrative Review.Canadian journal of kidney health and disease · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Safety of renal biopsy bleeding prophylaxis with desmopressin.The Journal of international medical research · 2021
    Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cynthia C LimDepartment of Renal Medicine, Singapore General Hospital, Academia Level 3, 20 College Road, Singapore, 169856, Singapore. cynthia.lim.c.w@singhealth.com.sg.ORCID http://orcid.org/0000-0003-0021-4861
Benson SiowPharmacy, Singapore General Hospital, 1 Hospital Drive, Outram Road, Singapore, Singapore.
Jason C J ChooDepartment of Renal Medicine, Singapore General Hospital, Academia Level 3, 20 College Road, Singapore, 169856, Singapore.
Mayank ChawlaDepartment of Renal Medicine, Singapore General Hospital, Academia Level 3, 20 College Road, Singapore, 169856, Singapore.
Yok Mooi ChinDepartment of Renal Medicine, Singapore General Hospital, Academia Level 3, 20 College Road, Singapore, 169856, Singapore.
Terence KeeDepartment of Renal Medicine, Singapore General Hospital, Academia Level 3, 20 College Road, Singapore, 169856, Singapore.
Puay Hoon LeePharmacy, Singapore General Hospital, 1 Hospital Drive, Outram Road, Singapore, Singapore.
Marjorie FooDepartment of Renal Medicine, Singapore General Hospital, Academia Level 3, 20 College Road, Singapore, 169856, Singapore.
Chieh Suai TanDepartment of Renal Medicine, Singapore General Hospital, Academia Level 3, 20 College Road, Singapore, 169856, Singapore.
Singapore General Hospital · SGSingHealth · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDesmopressin is used to reduce bleeding complications for kidney biopsies with azotemia but little is known about desmopressin-induced hyponatremia in these individuals. We aimed to evaluate the impact of desmopressin prophylaxis on severe hyponatremia and bleeding after kidney biopsies in individuals with renal impairment.

methodThis is a single-center retrospective cohort study of consecutive adults with serum creatinine ≥ 150 µmol/L and had ultrasound-guided percutaneous native or transplant kidney biopsies between June 2011 and July 2015. Data were retrieved from electronic medical records. Primary outcomes were the use of desmopressin prophylaxis and severe hyponatremia (serum sodium ≤ 125 mmol/L) within 7 days post-biopsy. Secondary outcome was post-biopsy bleeding.

results240 native kidney and 196 allograft biopsies were performed. Median age was 51 (IQR 42.3, 60) years and eGFR was 21.9 (12.9, 30.1) ml/min/1.73 m

conclusionPre-biopsy desmopressin was associated with severe hyponatremia in individuals with renal impairment; hence, susceptible patients given desmopressin should be closely monitored.

Indexed as

BiopsyCohort StudiesDeamino Arginine VasopressinFemaleHemostaticsHumansHyponatremiaKidneyMaleMiddle AgedPostoperative HemorrhageRetrospective StudiesTreatment OutcomeDeamino Arginine VasopressinHemostaticsChronic kidney diseaseElectrolyteGlomerulonephritisNeedle biopsy

Identifiers

PMID31028561
OpenAlexW2940753829

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.