ArticleJournal of neurology2019
Head tremor at disease onset: an ataxic phenotype of cervical dystonia.
Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Application of SPECT/CT muscle imaging in determining the involved muscles in cervical dystonia.Annals of nuclear medicine · 2026Article
- Article
- A study protocol for a randomized controlled trial to assess the effects of Baduanjin exercise on balance impairment in patients with cervical dystonia.Frontiers in neurology · 2025Article
- Thalamic ventral-Oralis complex/rostral zona incerta deep brain stimulation for midline tremor.Journal of neurology · 2024Article
- Sex Differences in Dystonia.Movement disorders clinical practice · 2024Article
- Comparing Essential Tremor with and without Soft Dystonic Signs and Tremor Combined with Dystonia: The TITAN Study.Movement disorders clinical practice · 2024Article
- Does Head Tremor Predict Postural Instability After Bilateral Thalamic Stimulation in Essential Tremor?Cerebellum (London, England) · 2023Article
- Pallidal Recordings in Chronically Implanted Dystonic Patients: Mitigation of Tremor-Related Artifacts.Bioengineering (Basel, Switzerland) · 2023Article
- Clinical features, pathophysiology, treatment, and controversies of tremor in dystonia.Journal of the neurological sciences · 2022Review
- Head tremor in cervical dystonia: Quantifying severity with computer vision.Journal of the neurological sciences · 2022Article
- Impaired Saccade Adaptation in Tremor-Dominant Cervical Dystonia-Evidence for Maladaptive Cerebellum.Cerebellum (London, England) · 2021Article
- Does Raising the Arms Modify Head Tremor Severity in Cervical Dystonia?Tremor and other hyperkinetic movements (New York, N.Y.) · 2021Article
- Head tremor and pain in cervical dystonia.Journal of neurology · 2021Article
- Tremor-Dominant Cervical Dystonia: a Cerebellar Syndrome.Cerebellum (London, England) · 2021Article
- The Dystonia Coalition: A Multicenter Network for Clinical and Translational Studies.Frontiers in neurology · 2021Review
- Tremor Syndromes: An Updated Review.Frontiers in neurology · 2021Review
- The Pathophysiology of Dystonic Tremors and Comparison With Essential Tremor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Tremor in Idiopathic Cervical Dystonia - Possible Implications for Botulinum Toxin Treatment Considering the Col-Cap Classification.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- Pallidal Activity in Cervical Dystonia with and Without Head Tremor.Cerebellum (London, England) · 2020Article
- Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia Registry.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 3 countries.
Funding
Abstract
backgroundCervical dystonia (CD) can present with head tremor. It is unclear whether ataxic features are differentially associated with this phenotype at onset of CD.
objectivesWe sought to evaluate: (1) the demographic features of CD patients with (Tr-CD) and without head tremor (nTr-CD) at onset, and (2) the differential ataxic features between these CD subtypes.
methodsFor the first objective, we compared demographic data in Tr-CD versus nTr-CD subtypes in the entire cohort of CD subjects enrolled in the Dystonia Coalition Natural History and Biorepository studies (n = 1608). For the second objective, we rated the standardized videos from consecutively enrolled Tr-CD subjects (n = 50) and age-, gender-, and disease duration-matched nTr-CD subjects (n = 50) for ataxia severity scoring using the Scale for the Assessment and Rating of Ataxia (SARA) and the International Cooperative Ataxia Rating Scale (ICARS); and for dystonia severity using the Toronto Western Spasmodic Torticollis Rating Scale section-I (TWSTRS) and the Global Dystonia Rating Scale (GDRS).
resultsOf 1,608 subjects, 18.1% (n = 291) were classified as Tr-CD and 81.9% (n = 1317) as nTr-CD. The Tr-CD cohort was older, predominantly female, and had longer disease duration than the nTr-CD cohort (p = 0.01). Compared to nTr-CD, Tr-CD subjects had worse generalized ataxia, speech, and gait and posture scores. High ataxia severity with low dystonia severity distinguished Tr-CD from nTr-CD with high accuracy (area under the curve, 0.91 (95% CI 0.85-0.97).
conclusionsHead tremor at disease onset represents a clinically distinguishable subtype of cervical dystonia affecting predominantly older women, with worse ataxia and milder dystonia than the non-tremulous dystonic phenotype.
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