ArticleJournal of neurology2019
Vertical nystagmus in Wernicke's encephalopathy: pathogenesis and role of central processing of information from the otoliths.
Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Downbeat nystagmus: a practical approach based on a clinical case.Arquivos de neuro-psiquiatria · 2026Article
- Astrocytopathy in Wernicke Encephalopathy and Neuromyelitis Optica Spectrum Disorder. Pathogenic Differences With Occasional Clinical and Neuroimaging Overlap. A Review.Current neurology and neuroscience reports · 2026Review
- Acute Vertigo, Dizziness and Imbalance in the Emergency Department-Beyond Stroke and Acute Unilateral Vestibulopathy-A Narrative Review.Brain sciences · 2025Review
- Alternating vertical nystagmus associated with Wernicke encephalopathy.Journal of neurology · 2025Article
- A Case of Bilateral Sudden Deafness Caused by Wernicke Encephalopathy.Journal of audiology & otology · 2025Article
- Upbeat nystagmus: a clinical and pathophysiological review.Frontiers in neurology · 2025Review
- Downbeat nystagmus: a clinical and pathophysiological review.Frontiers in neurology · 2024Review
- Generalized vestibular hyporeflexia and chronic upbeat nystagmus due to thiamine deficiency.Journal of neurology · 2023Article
- Spontaneous nystagmus with an upbeat component: Central or peripheral vestibular disorders?Frontiers in neurology · 2023Article
- Downbeat Nystagmus Is Abolished by Alcohol in Nonalcoholic Wernicke Encephalopathy.Neurology. Clinical practice · 2022Article
- Monocular Patching Attenuates Vertical Nystagmus in Wernicke's Encephalopathy via Release of Activity in Subcortical Visual Pathways.Movement disorders clinical practice · 2022Article
- The pharmacological treatment of acute vestibular syndrome.Frontiers in neurology · 2022Review
- Update on Nystagmus and Other Ocular Oscillations.Journal of clinical neurology (Seoul, Korea) · 2021Review
- The Use of Video-Head Impulse Test in Different Head Positions in Vertical Nystagmus and Ataxia Associated with Probable Thiamine Deficiency.Cerebellum (London, England) · 2020Article
- Vestibular Loss and Cerebellar Ataxia: A Practical Approach.Ear and hearingReview
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Wernicke's encephalopathy (WE) often have unusual patterns of vertical nystagmus. Initially there is often a spontaneous upbeating nystagmus that may change to downbeat nystagmus with a change in the direction of gaze, convergence or with vestibular stimuli. Patients also often show a profound loss of the horizontal but not the vertical vestibulo-ocular reflex (VOR). Furthermore, the acute upbeat nystagmus may change to a chronic downbeat nystagmus. We present hypotheses for these features based on (1) the location of vertical gaze-holding networks near the area postrema of the dorsomedial medulla where the blood-brain barrier is located, which we suggest becomes compromised in WE, (2) the location of the vestibular nuclei in the brainstem, medially for the horizontal VOR, and laterally for the vertical VOR, (3) neuronal circuits differ in susceptibility to and in the ability to recover from thiamine deficiency, and (4) impaired processing of otolith information in WE, normally used to modulate translational vestibulo-ocular reflexes, leads to some of the characteristics of the spontaneous vertical nystagmus including the peculiar reversal in its direction with a change in gaze or convergence.
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Registered trials
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