ArticleEuropean radiology2019
Standardized volumetric plaque quantification and characterization from coronary CT angiography: a head-to-head comparison with invasive intravascular ultrasound.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Standards for quantitative assessments by coronary computed tomography angiography (CCTA): An expert consensus document of the society of cardiovascular computed tomography (SCCT).Journal of cardiovascular computed tomographyGuideline
- Coronary Plaque Radiomic Phenotypes Predict Fatal or Nonfatal Myocardial Infarction: Analysis of the SCOT-HEART Trial.JACC. Cardiovascular imaging · 2025Trial
- Combined prognostic value of AI-derived CT-FFR and high-risk plaque characteristics in patients with newly diagnosed chronic coronary syndrome: a prospective cohort study.Frontiers in cardiovascular medicine · 2025Trial
- Machine Learning From Quantitative Coronary Computed Tomography Angiography Predicts Fractional Flow Reserve-Defined Ischemia and Impaired Myocardial Blood Flow.Circulation. Cardiovascular imaging · 2022Trial
- Association of coronary artery calcium score with qualitatively and quantitatively assessed adverse plaque on coronary CT angiography in the SCOT-HEART trial.European heart journal. Cardiovascular Imaging · 2022Trial
- Trial
- Repeatability of quantitative pericoronary adipose tissue attenuation and coronary plaque burden from coronary CT angiography.Journal of cardiovascular computed tomographyTrial
- High scan-rescan repeatability of AI-enabled coronary plaque quantification from coronary CT angiography.European radiology · 2026Article
- Mixed coronary plaque phantom analysis by photon-counting CT: impact of calcium and iodine on low-attenuation plaque detection.European heart journal. Imaging methods and practice · 2026Article
- Coronary plaque quantification on energy-integrating and photon-counting detector CT: reproducibility and power modeling for mixed-platform trials.European radiology · 2026Article
- Coronary CT Angiography for PCI Planning and Guidance: A Comprehensive Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Plaques Do Not Act Alone: Time to Redefine Coronary Vulnerability from Lesion to Phenotype.Journal of clinical medicine · 2025Review
- AI-quantified epicardial adipose tissue and prediction of future myocardial infarction in patients with cardiometabolic disease: a post-hoc analysis from the SCOT-HEART trial.Cardiovascular diabetology · 2025Article
- The plaque factor: Can coronary CT angiography plaque analysis link stenosis and ischemia?European radiology · 2025Article
- Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis.Nature reviews. Cardiology · 2025Review
- A systematic review on deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction.European journal of radiology open · 2025Article
- Implications of coronary calcification on the assessment of plaque pathology: a comparison of computed tomography and multimodality intravascular imaging.European radiology · 2025Article
- Assessment of coronary computed tomography angiography-derived plaque features in the diagnosis of optical coherence tomography-defined vulnerable plaques.Quantitative imaging in medicine and surgery · 2025Article
- Automatic vessel segmentation and reformation of non-contrast coronary magnetic resonance angiography using transfer learning-based three-dimensional U-net with attention mechanism.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Article
- Quantification of carotid artery plaque and peri-vascular adipose tissue attenuation on computed tomography.European heart journal. Imaging methods and practice · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectivesWe sought to evaluate the accuracy of standardized total plaque volume (TPV) measurement and low-density non-calcified plaque (LDNCP) assessment from coronary CT angiography (CTA) in comparison with intravascular ultrasound (IVUS).
methodsWe analyzed 118 plaques without extensive calcifications from 77 consecutive patients who underwent CTA prior to IVUS. CTA TPV was measured with semi-automated software comparing both scan-specific (automatically derived from scan) and fixed attenuation thresholds. From CTA, %LDNCP was calculated voxels below multiple LDNCP thresholds (30, 45, 60, 75, and 90 Hounsfield units [HU]) within the plaque. On IVUS, the lipid-rich component was identified by echo attenuation, and its size was measured using attenuation score (summed score ∕ analysis length) based on attenuation arc (1 = < 90°; 2 = 90-180°; 3 = 180-270°; 4 = 270-360°) every 1 mm.
resultsTPV was highly correlated between CTA using scan-specific thresholds and IVUS (r = 0.943, p < 0.001), with no significant difference (2.6 mm
conclusionsStandardized noninvasive plaque quantification from CTA using scan-specific thresholds correlates highly with IVUS. Use of a < 45-HU threshold for LDNCP quantification improves lipid-rich plaque assessment from CTA. KEY POINTS: • Standardized scan-specific threshold-based plaque quantification from coronary CT angiography provides an accurate total plaque volume measurement compared with intravascular ultrasound. • Attenuation histogram-based low-density non-calcified plaque quantification can improve lipid-rich plaque assessment from coronary CT angiography.
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