Evidence map›Paper›PMID 31028426›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2019

DNA damage in blood leucocytes of prostate cancer patients during therapy with

Sarah Schumann, Harry Scherthan, Constantin Lapa, Sebastian Serfling, Razan Muhtadi, Michael Lassmann, Uta Eberlein

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Review
  7. Cardiovascular disease and radiopharmaceutical therapies- an underestimated risk?European journal of nuclear medicine and molecular imaging · 2025
    Article
  8. Review
  9. DNA Damage and Repair in PBMCs after Internal Ex Vivo Irradiation with [International journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. EANM position paper on the role of radiobiology in nuclear medicine.European journal of nuclear medicine and molecular imaging · 2021
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sarah SchumannDepartment of Nuclear Medicine, University of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany. Schumann_S1@ukw.de.ORCID http://orcid.org/0000-0003-4303-7068
Harry ScherthanBundeswehr Institute of Radiobiology affiliated to the University of Ulm, Neuherbergstr. 11, 80937, Munich, Germany.
Constantin LapaDepartment of Nuclear Medicine, University of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Sebastian SerflingDepartment of Nuclear Medicine, University of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Razan MuhtadiBundeswehr Institute of Radiobiology affiliated to the University of Ulm, Neuherbergstr. 11, 80937, Munich, Germany.
Michael LassmannDepartment of Nuclear Medicine, University of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Uta EberleinDepartment of Nuclear Medicine, University of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
University of Würzburg · DEUniversität Ulm · DE

Funding

Deutsche Forschungsgemeinschaft LA 2304/3-2Deutsche Forschungsgemeinschaft SCHE 350/12-2
6 · The paper itself

Abstract

purposeThe aim of this study was to investigate the time- and dose-dependency of DNA double-strand break (DSB) induction and repair in peripheral blood leucocytes of prostate cancer patients during therapy with

methodsBlood samples from 16 prostate cancer patients receiving their first

resultsThe average number of radiation-induced foci (RIF) per cell increased within the first 4 h after administration, followed by a decrease indicating DNA repair. The number of RIF during the first 2.6 h correlated linearly with the absorbed dose to the blood (R

conclusionThe general pattern of the time- and dose-dependent induction and disappearance of RIF during

Indexed as

DNA DamageAgedAged, 80 and overDipeptidesDNA Breaks, Double-StrandedDose-Response Relationship, RadiationHeterocyclic Compounds, 1-RingHumansLeukocytesLutetiumMaleMiddle AgedProstate-Specific AntigenProstatic NeoplasmsRadiopharmaceuticalsRadiotherapy DosageDipeptidesHeterocyclic Compounds, 1-RingLutetiumPluvictoProstate-Specific AntigenRadiopharmaceuticals177Lu-PSMA53BP1Absorbed dose to the bloodBiodosimetryDNA double-strand breaksProstate cancerγ-H2AX

Identifiers

PMID31028426
PMCPMC6584247
OpenAlexW2941372839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.