ArticleThe Journal of infectious diseases2019
Households or Hotspots? Defining Intervention Targets for Malaria Elimination in Ratanakiri Province, Eastern Cambodia.
Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Residual Malaria Transmission in Select Countries of Asia-Pacific Region: Old Wine in a New Barrel.The Journal of infectious diseases · 2021Pooled it
- Pooled it
- Could prophylactic antivirals reduce dengue incidence in a high-prevalence endemic area?PLoS neglected tropical diseases · 2024Article
- Using serological diagnostics to characterize remaining high-incidence pockets of malaria in forest-fringe Cambodia.Malaria journal · 2024Article
- Heterogeneity in prevalence of subclinical Plasmodium falciparum and Plasmodium vivax infections but no parasite genomic clustering in the Chittagong Hill Tracts, Bangladesh.Malaria journal · 2022Article
- Dry Post Wintertime Mass Surveillance Unearths a Huge Burden ofPathogens (Basel, Switzerland) · 2021Article
- Forest malaria in Cambodia: the occupational and spatial clustering of Plasmodium vivax and Plasmodium falciparum infection risk in a cross-sectional survey in Mondulkiri province, Cambodia.Malaria journal · 2020Article
- Malaria elimination using the 1-3-7 approach: lessons from Sampov Loun, Cambodia.BMC public health · 2020Article
- Feasibility of pharmacy-based research opportunity to enhance community testing and surveillance.Journal of the American Pharmacists Association : JAPhAArticle
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalaria "hotspots" have been proposed as potential intervention units for targeted malaria elimination. Little is known about hotspot formation and stability in settings outside sub-Saharan Africa.
methodsClustering of Plasmodium infections at the household and hotspot level was assessed over 2 years in 3 villages in eastern Cambodia. Social and spatial autocorrelation statistics were calculated to assess clustering of malaria risk, and logistic regression was used to assess the effect of living in a malaria hotspot compared to living in a malaria-positive household in the first year of the study on risk of malaria infection in the second year.
resultsThe crude prevalence of Plasmodium infection was 8.4% in 2016 and 3.6% in 2017. Living in a hotspot in 2016 did not predict Plasmodium risk at the individual or household level in 2017 overall, but living in a Plasmodium-positive household in 2016 strongly predicted living in a Plasmodium-positive household in 2017 (Risk Ratio, 5.00 [95% confidence interval, 2.09-11.96], P < .0001). There was no consistent evidence that malaria risk clustered in groups of socially connected individuals from different households.
conclusionsMalaria risk clustered more clearly in households than in hotspots over 2 years. Household-based strategies should be prioritized in malaria elimination programs in this region.
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