Evidence map›Paper›PMID 31028179›Full record

ArticleJournal of cell science2019

Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse.

Samantha C Salvage, Esther M Gallant, Nicole A Beard, Shiraz Ahmad, Haseeb Valli, James A Fraser, Christopher L-H Huang, Angela F Dulhunty

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Stem cell models of inherited arrhythmias.Nature cardiovascular research · 2024
    Review
  4. Arrhythmogenic mechanism of a novel ryanodine receptor mutation underlying sudden cardiac death.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  5. Advances in basic and translational research in atrial fibrillation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  6. Feedback contributions to excitation-contraction coupling in native functioning striated muscle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  7. FKBP12 binds to the cardiac ryanodine receptor with negative cooperativity: implications for heart muscle physiology in health and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  8. How does flecainide impact RyR2 channel function?The Journal of general physiology · 2022
    Article
  9. A novel mutation in ryanodine receptor 2 (Frontiers in pediatrics · 2022
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Samantha C SalvagePhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.ORCID 0000-0002-5793-2349
Esther M GallantEccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, 131 Garran Road, Acton ACT 2601, Australia.
Nicole A BeardCentre for Research in Therapeutic Solutions, Faculty of Science and Technology, University of Canberra, Bruce, ACT 2617, Australia.ORCID 0000-0002-8212-2209
Shiraz AhmadPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.
Haseeb ValliPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.
James A FraserPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.ORCID 0000-0002-6505-1883
Christopher L-H HuangPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.ORCID 0000-0001-9553-6112
Angela F DulhuntyEccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, 131 Garran Road, Acton ACT 2601, Australia angela.dulhunty@anu.edu.au.ORCID 0000-0001-9493-4944
University of Cambridge · GBAustralian National University · AUUniversity of Canberra · AU

Funding

British Heart Foundation PG/14/79/31102British Heart Foundation PG/15/12/31280Medical Research Council MR/M001288/1Wellcome TrustWellcome Trust 105727/Z/14/Z
6 · The paper itself

Abstract

Mutations in the cardiac ryanodine receptor Ca

Indexed as

AnimalsArrhythmias, CardiacAtrial FibrillationCalciumCytoplasmIon Channel GatingMiceMyocytes, CardiacPhosphorylationRyanodine Receptor Calcium Release ChannelCalciumryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelAtrial fibrillationCatecholaminergic polymorphic ventricular tachycardiaCytoplasmic Ca2+ activationCytoplasmic Ca2+ inactivationFKBPP2328S-RyR2 mouseRyR2 P2328S ion channel

Identifiers

PMID31028179
PMCPMC6550012
OpenAlexW2941551554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.