ArticleProceedings of the National Academy of Sciences of the United States of America2019
Dynamic super-resolution structured illumination imaging in the living brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- SIMworks-an integrated software suite for quality-controlled augmented quantitative structured illumination microscopy.Nature protocols · 2026Review
- Background-free quantitative phase imaging with adaptive-optics surface plasmon resonance holographic microscopy.Light, science & applications · 2026Article
- Dual deconvolution in multiphoton structured illumination microscopy for deep-tissue super-resolution imaging.Nature communications · 2026Article
- Optical Approaches to Dissect the Structure and Dynamics of the Synapse at Nanoscale Resolution.Advances in neurobiology · 2026Review
- Visualizing intraorganellar ultrastructures, dynamics, and interactions with open-access background-free Lock-in-SIM.Nature communications · 2025Article
- Deep3DSIM: Super-resolution imaging of thick tissue using 3D structured illumination with adaptive optics.eLife · 2025Article
- Article
- Super-resolution upgrade for deep tissue imaging featuring simple implementation.Nature communications · 2025Article
- Super-resolution imaging of fast morphological dynamics of neurons in behaving animals.Nature methods · 2025Article
- Fortunate molecules boost signal to background ratio and localization precision in correlation based single molecule localization microscopy.Communications biology · 2024Article
- Extended-depth of field random illumination microscopy, EDF-RIM, provides super-resolved projective imaging.Light, science & applications · 2024Article
- OpenSTED: open-source dynamic intensity minimum system for stimulated emission depletion microscopy.Neurophotonics · 2024Article
- Three-photon excited fluorescence microscopy enables imaging of blood flow, neural structure and inflammatory response deep into mouse spinal cordbioRxiv : the preprint server for biology · 2024Article
- Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders.Frontiers in aging neuroscience · 2024Review
- Tandem aberration correction optics (TACO) in wide-field structured illumination microscopy.Biomedical optics express · 2023Article
- Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023Article
- Deep learning-driven adaptive optics for single-molecule localization microscopy.Nature methods · 2023Article
- Scanning single molecule localization microscopy (scanSMLM) for super-resolution volume imaging.Communications biology · 2023Article
- Label-free adaptive optics single-molecule localization microscopy for whole zebrafish.Nature communications · 2023Article
- Superresolution structured illumination microscopy reconstruction algorithms: a review.Light, science & applications · 2023Review
1 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
Cells in the brain act as components of extended networks. Therefore, to understand neurobiological processes in a physiological context, it is essential to study them in vivo. Super-resolution microscopy has spatial resolution beyond the diffraction limit, thus promising to provide structural and functional insights that are not accessible with conventional microscopy. However, to apply it to in vivo brain imaging, we must address the challenges of 3D imaging in an optically heterogeneous tissue that is constantly in motion. We optimized image acquisition and reconstruction to combat sample motion and applied adaptive optics to correcting sample-induced optical aberrations in super-resolution structured illumination microscopy (SIM) in vivo. We imaged the brains of live zebrafish larvae and mice and observed the dynamics of dendrites and dendritic spines at nanoscale resolution.
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