ArticleNeurology2019
Assessing for interaction between
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In one paragraph
Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
–field-weighted citation impact
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Who cites it
24 citing papers in PubMed.
- Shared genetic and molecular architecture between insulin resistance and cognitive performance.medRxiv : the preprint server for health sciences · 2026Article
- Walking to protect against cognitive decline: the role of APOE genotype and sex.Biology of sex differences · 2026Article
- Sex differences in cognitive trajectories and practice effects in a cohort of older Londoners: The role of risk factors.Journal of Alzheimer's disease : JAD · 2025Article
- Associations and interactions betweenBrain communications · 2025Article
- Effect of apolipoprotein E ε4 and its modification by sociodemographic characteristics on cognitive measures in South Asians from LASI-DAD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Socioeconomic status, lifestyle and risk of incident dementia: a prospective cohort study of 276730 participants.GeroScience · 2024Article
- The interaction effects of age, APOE and common environmental risk factors on human brain structure.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Head motion in the UK Biobank imaging subsample: longitudinal stability, associations with psychological and physical health, and risk of incomplete data.Brain communications · 2024Article
- Hormone replacement therapy, menopausal age and lifestyle variables are associated with better cognitive performance at follow-up but not cognition over time in older-adult women irrespective of APOE4 carrier status and co-morbidities.Frontiers in dementia · 2024Article
- Involvement of APOE in Incidence of Revascularization in Patients Affected by Peripheral Arterial Disease: A Prospective Study from Southern Italy.Journal of clinical medicine · 2023Article
- Harnessing the potential of machine learning and artificial intelligence for dementia research.Brain informatics · 2023Review
- APOE genotype, hippocampus, and cognitive markers of Alzheimer's disease in American Indians: Data from the Strong Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases.Molecular neurodegeneration · 2022Review
- Serum ω-3 Fatty Acids and Cognitive Domains in Community-Dwelling Older Adults from the NuAge Study: Exploring the Associations with Other Fatty Acids and Sex.The Journal of nutrition · 2022Article
- Greenspace and mortality in the U.K. Biobank: Longitudinal cohort analysis of socio-economic, environmental, and biomarker pathways.SSM - population health · 2022Article
- Vigorous Physical Activity and Cognitive Trajectory Later in Life: Prospective Association and Interaction by Apolipoprotein E e4 in the Nurses' Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Quantifying bias in psychological and physical health in the UK Biobank imaging sub-sample.Brain communications · 2022Article
- Effects of sex and genotype in human APOE-targeted replacement mice on alcohol self-administration measured with the automated IntelliCage system before and after repeated mild traumatic brain injury.Alcoholism, clinical and experimental research · 2021Article
- Hypertension and Hypercholesterolemia Modify Dementia Risk in Relation to APOEɛ4 Status.Journal of Alzheimer's disease : JAD · 2021Article
- Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Donald M LyallFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden. Donald.Lyall@Glasgow.ac.uk.
Carlos Celis-MoralesFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.
Laura M LyallFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.
Christopher GrahamFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.
Nicholas GrahamFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.
Daniel F MackayFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.
Rona J StrawbridgeFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.ORCID 0000-0001-8506-3585
Joey WardFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.
Jason M R GillFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.
Naveed SattarFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.
Jonathan CavanaghFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.
Daniel J SmithFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.
Jill P PellFrom the Institute of Health & Wellbeing (D.M.L., L.M.L., C.G., N.G., D.F.M., R.J.S., J.W., J.C., D.J.S., J.P.P.) and Institute of Cardiovascular and Medical Sciences (C.C.-M., J.M.R.G., N.S.), University of Glasgow, Scotland, UK; and Department of Medicine Solna (R.J.S.), Karolinska Institute, Stockholm, Sweden.
Funding
Medical Research Council MC_PC_17217Medical Research Council MR/S003061/1
Abstract
objectiveTo test for interactions between
methodsUsing UK Biobank cohort data, we tested for interactions between
resultsThere were significant associations between
conclusionsOur results do not provide support for the idea that ε4 genotype increases vulnerability to the negative effects of lifestyle risk factors on cognitive ability, but rather support a primarily outright association between
Indexed as
CognitionExerciseAlcohol DrinkingApolipoprotein E4Biological Specimen BanksCohort StudiesExecutive FunctionFemaleGene-Environment InteractionGenotypeHumansMaleMiddle AgedObesitySex FactorsSmokingApolipoprotein E4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.