Evidence map›Paper›PMID 31028120›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K

Xuejiao Dong, Lisi Wei, Xueheng Guo, Zhiyong Yang, Chuan Wu, Peiyu Li, Lu Lu, Hai Qi, Yan Shi, Xiaoyu Hu and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Frontiers in pharmacology · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Xuejiao DongMinistry of Education Key Laboratory of Protein Sciences, Center for Life Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Beijing Key Laboratory for Immunological Research on Chronic Diseases, Institute for Immunology, Tsinghua University, Beijing 100084, China.
Lisi WeiState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing 100871, China.
Xueheng GuoInstitute for Immunology, School of Medicine, Tsinghua University, Beijing 100084, China.
Zhiyong YangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143.ORCID 0000-0003-0589-6224
Chuan WuExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20851.
Peiyu LiKey Laboratory of Medical Molecular Virology of the Ministry of Education/Ministry of Health, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China.ORCID 0000-0002-1001-7485
Lu LuKey Laboratory of Medical Molecular Virology of the Ministry of Education/Ministry of Health, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China.
Hai QiInstitute for Immunology, School of Medicine, Tsinghua University, Beijing 100084, China.ORCID 0000-0001-5475-3989
Yan ShiInstitute for Immunology, School of Medicine, Tsinghua University, Beijing 100084, China.
Xiaoyu HuInstitute for Immunology, School of Medicine, Tsinghua University, Beijing 100084, China.
Li WuInstitute for Immunology, School of Medicine, Tsinghua University, Beijing 100084, China; liulab@tsinghua.edu.cn wuli@tsinghua.edu.cn lychen@pku.edu.cn.
Liangyi ChenState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing 100871, China; liulab@tsinghua.edu.cn wuli@tsinghua.edu.cn lychen@pku.edu.cn.
Wanli LiuMinistry of Education Key Laboratory of Protein Sciences, Center for Life Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Beijing Key Laboratory for Immunological Research on Chronic Diseases, Institute for Immunology, Tsinghua University, Beijing 100084, China; liulab@tsinghua.edu.cn wuli@tsinghua.edu.cn lychen@pku.edu.cn.ORCID 0000-0003-0395-2800
Tsinghua University · CNMinistry of Education · KRPeking University · CNShanghai Medical College of Fudan University · CNNational Board of Examinations · INNational Institutes of Health · USUniversity of California, San Francisco · US

Funding

The role of Foxo1 for intestinal epithelial cells during mucosal immune responseZIABC011755 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WU, CHUAN · 2017 to 2025
$4.1M
T cell regulation for intestinal barrier functionZIABC011801 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WU, CHUAN · 2018 to 2025
$4.1M
Intramural NIH HHS ZIA BC011755
6 · The paper itself

Abstract

Dendritic cells (DCs) play key roles in Ab responses by presenting Ags to lymphocytes and by producing proinflammatory cytokines. In this study, we reported that DC-specific knockout of discs large homologue 1 (Dlg1) resulted in a significantly reduced capacity to mediate Ab responses to both thymus-independent and thymus-dependent Ags in

Indexed as

AnimalsAntibody FormationAntigen PresentationCalcium SignalingCells, CulturedCytokinesDendritic CellsDiscs Large Homolog 1 ProteinEndocytosisGene Expression RegulationMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutPotassium Channels, Voltage-GatedCytokinesDiscs Large Homolog 1 ProteinDlg1 protein, mousePotassium Channels, Voltage-Gated

Identifiers

PMID31028120
PMCPMC8323592
OpenAlexW2942284280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.