Evidence map›Paper›PMID 31028114›Full record

ArticleGenetics2019

DNA Rereplication Is Susceptible to Nucleotide-Level Mutagenesis.

Duyen T Bui, Joachim J Li

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. NAR genomics and bioinformatics · 2021
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Duyen T BuiDepartment of Microbiology and Immunology, University of California San Francisco, California 94143.ORCID 0000-0003-4231-0587
Joachim J LiDepartment of Microbiology and Immunology, University of California San Francisco, California 94143 Joachim.Li@ucsf.edu.ORCID 0000-0002-5302-8897
University of California, San Francisco · US

Funding

Role of regulation of eukaryotic DNA replication in preserving genomic stabilityR01GM059704 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, JOACHIM J · 2000 to 2019
$5.4M
NIGMS NIH HHS R01 GM059704
6 · The paper itself

Abstract

The sources of genome instability, a hallmark of cancer, remain incompletely understood. One potential source is DNA rereplication, which arises when the mechanisms that prevent the reinitiation of replication origins within a single cell cycle are compromised. Using the budding yeast

Indexed as

DNA Mismatch RepairDNA ReplicationFrameshift MutationGenomic InstabilityMutagenesisAmino Acid Transport Systems, BasicExodeoxyribonucleasesMutationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAmino Acid Transport Systems, BasicCAN1 protein, S cerevisiaeExodeoxyribonucleasesSaccharomyces cerevisiae ProteinsDNA polymerase proofreadingDNA replication fidelitygenome instabilitymismatch repairrereplication

Identifiers

PMID31028114
PMCPMC6553831
OpenAlexW2942304204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.