Evidence map›Paper›PMID 31027994›Full record

ArticleMolecular metabolism2019

Noggin depletion in adipocytes promotes obesity in mice.

Ana M Blázquez-Medela, Medet Jumabay, Prashant Rajbhandari, Tamer Sallam, Yina Guo, Jiayi Yao, Laurent Vergnes, Karen Reue, Li Zhang, Yucheng Yao and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Ana M Blázquez-MedelaDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Medet JumabayDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Prashant RajbhandariHuman Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Tamer SallamDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Yina GuoDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Jiayi YaoDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Laurent VergnesHuman Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Karen ReueHuman Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Li ZhangDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Yucheng YaoDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Alan M FogelmanDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Peter TontonozPathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Aldons J LusisDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Xiuju WuDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: xiujuwu@mednet.ucla.edu.
Kristina I BoströmDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Molecular Biology Institute, UCLA, USA. Electronic address: kbostrom@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 1985 to 2019
$50.2M
The Lipin Protein Family and Triglyceride Metabolism P01HL090553 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2008 to 2018
$23.3M
Molecular Mechanisms of MGP; Role in AVMsR01HL081397 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2006 to 2025
$7.7M
BMP and Notch Crosstalk in Cerebral Arteriovenous MalformationsR01NS079353 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yucheng Yao · 2012 to 2026
$5.3M
Switch of Osteogenesis in Vascular CalcificationR01HL139675 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yucheng Yao · 2018 to 2026
$3.6M
RNA-binding proteins in atherosclerosisR01HL139549 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tamer Sallam · 2018 to 2026
$3.3M
Long Non-coding RNAs in the Regulation of Adipogenesis and ObesityR01DK118086 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SALLAM, TAMER · 2018 to 2022
$1.9M
Role of The Endothelium In Vascular CalcificationR01HL112839 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOSTROM, KRISTINA I · 2013 to 2016
$1.5M
Interleukin-10 Signaling in Adipose Tissue Thermogenesis and Energy expenditureK99DK114571 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAJBHANDARI, PRASHANT · 2018 to 2019
$180k
XF24-3 Extracellular Flux AnalyzerS10RR026744 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REUE, KAREN · 2010 to 2010
$168k
NCI NIH HHS P30 CA016042NCRR NIH HHS S10 RR026744NHLBI NIH HHS P01 HL028481NHLBI NIH HHS P01 HL030568NHLBI NIH HHS R01 HL081397NHLBI NIH HHS R01 HL112839NHLBI NIH HHS R01 HL139549NHLBI NIH HHS R01 HL139675NIDDK NIH HHS K99 DK114571NIDDK NIH HHS R01 DK118086NINDS NIH HHS R01 NS079353
6 · The paper itself

Abstract

objectiveObesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin is largely unknown. The aim of the study was to define the role of Noggin, an extracellular BMP inhibitor, in adipogenesis.

methodsWe generated adipose-derived progenitor cells and a mouse model with adipocyte-specific Noggin deletion using the Adiponectin

resultsOur studies showed that Noggin is expressed in progenitor cells but declines in adipocytes, possibly allowing for lipid accumulation. Correspondingly, adipocyte-specific Noggin deletion in vivo promoted age-related obesity in both genders with no change in food intake. Although the loss of Noggin caused white adipose tissue hypertrophy, and whitening and impaired function in brown adipose tissue in both genders, there were clear gender differences with the females being most affected. The females had suppressed expression of brown adipose markers and thermogenic genes including peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC1alpha) and uncoupling protein 1 (UCP1) as well as genes associated with adipogenesis and lipid metabolism. The males, on the other hand, had early changes in a few BAT markers and thermogenic genes, but the main changes were in the genes associated with adipogenesis and lipid metabolism. Further characterization revealed that both genders had reductions in VO

conclusionsBMP signaling regulates female and male adipogenesis through different metabolic pathways. Modulation of adipose tissue metabolism by select BMP antagonists may be a strategy for long-term regulation of age-related weight gain and obesity.

Indexed as

AdipocytesAdipogenesisAdipose TissueAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsBone Morphogenetic ProteinsCarrier ProteinsDisease Models, AnimalEatingFemaleGene DeletionGene Expression RegulationGenetic Association StudiesLipid Accumulation ProductLipid MetabolismBone Morphogenetic ProteinsCarrier ProteinsNoggin ProteinPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseUcp1 protein, mouseUncoupling Protein 1AdipocyteAdipogenesisBone morphogenetic proteinNogginObesity

Identifiers

PMID31027994
PMCPMC6600080
OpenAlexW2936956362

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.