Evidence map›Paper›PMID 31027947›Full record

ReviewTransplantation reviews (Orlando, Fla.)2019

Transplant research in nonhuman primates to evaluate clinically relevant immune strategies in organ transplantation.

Zachary Fitch, Robin Schmitz, Jean Kwun, Bernhard Hering, Joren Madsen, Stuart J Knechtle

Abstract readReview
In one paragraph

Review in Transplantation reviews (Orlando, Fla.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Experimental modeling of desensitization: What have we learned about preventing AMR?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zachary FitchDepartment of Surgery, Duke Transplant Center, Durham, NC 27710, USA; Center for Transplantation Sciences, Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, White 510c, 55 Fruit Street, Boston, MA, USA.
Robin SchmitzDepartment of Surgery, Duke Transplant Center, Durham, NC 27710, USA.
Jean KwunDepartment of Surgery, Duke Transplant Center, Durham, NC 27710, USA.
Bernhard HeringSchulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
Joren MadsenDepartment of Surgery, Duke Transplant Center, Durham, NC 27710, USA.
Stuart J KnechtleDepartment of Surgery, Duke Transplant Center, Durham, NC 27710, USA. Electronic address: stuart.knechtle@duke.edu.

Funding

Transplant Tolerance in Non-Human PrimatesU19AI051731 · NIAID · UNIVERSITY OF WESTERN ONTARIO · PI LARSEN, CHRISTIAN P. · 2002 to 2022
$54.1M
XENOGENIC TOLERANCE IN MICEP01HL018646 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1985 to 2019
$37.5M
The Risks and Opportunities of Homeostatic RepopulationU19AI131471 · NIAID · DUKE UNIVERSITY · PI Andrew Serghios Barbas · 2017 to 2026
$30.4M
Project 3: The Role of Erythropoietin in Kidney Transplant ToleranceP01AI123086 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2016 to 2020
$10.6M
Advancing Islet Transplants for Type 1 Diabetes CareU01AI065193 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HERING, BERNHARD JOSEF · 2004 to 2008
$9.3M
Mixed chimerism induced tolerance in heart recipients requires donor kidney cotransplantationU01AI131470 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2017 to 2022
$5.6M
TOLERANCE TO ISLET ALLOGRAFTS IN TYPE I DIABETESR01DK056963 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HERING, BERNHARD JOSEF · 2000 to 2005
$4.5M
Alloantigen Delivery Via ECDI-Fixed Cells For Tolerance To Monkey Islet GraftsU01AI102463 · NIAID · UNIVERSITY OF MINNESOTA · PI HERING, BERNHARD JOSEF, LUO, XUNRONG · 2012 to 2016
$4.4M
CARDIAC ALLOGRAFT VASCULOPATHY IN MINIATURE SWINER01HL054211 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ROSENGARD, BRUCE R · 1996 to 2008
$3.6M
Stimulating Access to Research in Residency (StARR) - NIAIDR38AI140297 · NIAID · DUKE UNIVERSITY · PI Rachel G Greenberg, David H. Harpole · 2018 to 2026
$2.4M
NHLBI NIH HHS P01 HL018646NHLBI NIH HHS R01 HL054211NIAID NIH HHS P01 AI123086NIAID NIH HHS R38 AI140297NIAID NIH HHS U01 AI065193NIAID NIH HHS U01 AI102463NIAID NIH HHS U01 AI131470NIAID NIH HHS U19 AI051731NIAID NIH HHS U19 AI131471NIDDK NIH HHS R01 DK056963
6 · The paper itself

Abstract

Research in transplant immunology using non-human primate (NHP) species to evaluate immunologic strategies to prevent rejection and prolong allograft survival has yielded results that have translated successfully into human organ transplant patient management. Other therapies have not proceeded to human translation due to failure in NHP testing, arguably sparing humans the futility and risk of such testing. The NHP transplant models are ethically necessary for drug development in this field and provide the closest analogue to human transplant patients available. The refinement of this resource with respect to colony MHC typing, reagent and assay development, and availability to the research community has greatly enhanced knowledge about transplant immunology and drug development.

Indexed as

Organ TransplantationTransplantation ImmunologyAnimalsBiomedical ResearchModels, AnimalPrimates

Identifiers

PMID31027947
PMCPMC6599548

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.